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33 Cards in this Set
- Front
- Back
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Irreversible cyclooxygenase inhibitors
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aspirin
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Adenosine diphosphate (ADP) receptor inhibitors
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clopidogrel, ticlopidine,prasugrel, ticagrelor
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PDE inhibitors
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cilostazol
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glycoprotein IIB/IIIA inhibitors
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abciximab, eptifibatide, tirofiban
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Prasugrel trade name?
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(Effient)
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Ticagrelor trade name?
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(Brilinta)
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Ticlopidine trade name?
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(Ticlid)
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Cilostazol trade name?
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(Pletal)
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Abciximab trade name?
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(ReoPro)
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Eptifibatide trade name?
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(Integrilin)
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Tirofiban trade name?
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(Aggrastat)
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Dipyridamole trade name?
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(Persantine)
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irreversibly inhibits the enzyme COX, resulting in reduced platelet production of TXA2
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aspirin
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powerful vasoconstrictor that lowers cyclic AMP and initiates the platelet release reaction
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thromboxane
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inhibits platelet phosphodiesterase, causing an increase in cyclic AMP with potentiation of the action of PGI2 – opposes actions of TXA2 / Adenosine reuptake inhibitor
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dipyridamole
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affects the ADP-dependent activation of IIb/IIIa complex
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clopidogrel
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block a receptor on the platelet for fibrinogen and von Willebrand factor
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glycoprotein IIb/IIIa receptor antagonists
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a prostacyclin that is used to inhibit platelet aggregation during renal dialysis
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Epoprostenol
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forms a complex with plasminogen, resulting in a conformational change that activates other plasminogen molecules to form plasmin
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streptokinase
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Direct Xa inhibitors
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Rivaroxaban
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Direct thrombin (II) inhibitors (bivalent)
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bivalirudin, desirudin, lepirudin
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Direct thrombin (II) inhibitors (univalent)
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argatroban, dabigatran
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Factor Xa inhibitors
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LMWH; fondaparinux
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fondaparinux trade name?
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Arixtra
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rivaroxaban trade name?
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Xarelto
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bivalirudin trade name?
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Angiomax
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a naturally occurring peptide in the salivary glands of medicinal leeches
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hirudin
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argatroban trade name?
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none (argatroban)
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dabigatran trade name?
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Pradaxa
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FDA approval for Xarelto
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nonvalvular AF CvA prevention; DVT prophylaxis in knee and hip surgery
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main indication for bivalirudin and argatroban
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acute anticoagulation in HIT
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oral anticoagulation agent
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dabigatran
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indication for dabigatran
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nonvalvular Afib CVA prevention
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