Antiparkinsons Drugs

Front 1

What are 2 factors that help decide which drugs to use for Parkinson's patients?

Back 1

1)severity of disease
2)ability to tolerate side effects

Front 2

In Parkinson's, what happens to dopamine and cholinergic levels in the body?

Back 2

There is decreased dopaminergic activity and increased cholinergic activity.

Front 3

what are 3 therapeutic strategies for treating Parkinson's?

Back 3

1) increase dopamine concentration and receptor activity
2) inhibit the metabolism/breakdown of dopamine
3) anticholinergic drugs (reduce cholingergic activity, as an adjunctive therapy

Front 4

In Parkinson's, can use of drugs eliminate or cure the disease?

Back 4

NO! drugs can reduce symptoms and improve condition, but cannot fix the problem

Front 5

what is the name of the drug used in PK that is a metabolic precursor of dopamine?

Back 5

Levodopa

Front 6

what drug used in PK is a dopamine agonist?

Back 6

bromocriptine (parlodel)

Front 7

what drug for PK inhibits metabolism of dopamine?

Back 7

selegiline (eldepryl)

Front 8

what drug used in PK is an anticholinergic?

Back 8

benztropine (cogentin)

Front 9

an example of a monoamine oxidase inhibitor is:
-benztropine
-selegiline
-bromocriptine

Back 9

selegiline

Front 10

what should you know about benztropine?

Back 10

-used as an adjunct drug in Parkinsons and in drug induced extra-pyramidal disorders (as caused by antipsychotics)
-alleviate tremors and rigidity
-causes mood changes, dry mouth, blurred vision, constipation, and urinary retention

Front 11

what should you know about selegiline?
(effects, uses)

Back 11

-used as adjunct therapy with levodopa/carbidopa
-use for slow progression of disease
-causes nausea, dizziness, lightheadedness, abdom. pain, dry mouth, headache, vivid dreams and hallucinations

Front 12

what should you know about bromocriptine (effects)?

Back 12

-used with Levodopa
-no effect on pts. who do not respond ot levodopa
-similar side effects to levodopa, except lesson common dyskinesia
-causes hallucinations, confusion, delirium, nausea, ortho. hypotension

Front 13

what are the main effects (therapeutic and side) for levodopa?

Back 13

-decrease rigidity and tremors
-tolerance from long term use
-on-off phenomenon
-psychological disorders
-nausea, vomiting, anorexia, tachycardia, post. hypotension
-mydriasis
-dykinesia

Front 14

what is carbidopa used in conjunction with?

Back 14

it is used with levodopa, it inhibits the metabolism of levodopa in the GI tract and peripheral tissues

Front 15

as OTs, what should we think about with PK pts.?

Back 15

-work on gait training and balance activities
-help pt. keep function to eliminate need for more drugs
-maintain joint ROM and cardio fitness during drug holidays

Front 16

Which drug for PK might a pt. take a drug holiday?

Back 16

Levodopa, because tolerance can develop with long term use

Front 17

bradykinesia, postural/gait abnormalities, tremors, and muscular rigidity

These are characteristics of what?

Back 17

Parkinson's Disease

Front 18

Which is not a sign of Parkinson's?
-impaired speech
-cognitive delays
-shuffling gait
-blank facial expression
-inability to perform skilled tasks

Back 18

cognitive delays