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36 Cards in this Set
- Front
- Back
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metronidazole MOA
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active form breaks DNA and prevents nucleic acid synthesis
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activation of metronidazole
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reduced ferredoxin (from deCO2 of pyruvate) or nitroreductase (create NADP in the process) transfers e-
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metronidazole is effective against what kind of organisms
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anaerobics:
giardia entamoeba histolytica trichomonas vaginalis |
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tx of amebiasis in the bowel wall or liver (tissuecidal)
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metronidazole
tinidazole |
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tx of amebiasis in the GI lumen
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iodoquinol
paromomycin |
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used to tx asymptomatic amebiasis
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iodoquinol
paromomycin |
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used to tx symptomatic amebiasis
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metronidazole
tinidiazole |
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turns urine red-brown
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metronidazole
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causes iodine toxicity (fever, itching, dermatitis)
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iodoquinol
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causes thyroid enlargement and altered thyroid function tests
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iodoquinol
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causes subacute myelo-optic neuropathy (muscle pain, weakness, optic atrophy, and ataxia)
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iodoquinol
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MOA of paromomycin
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aminoglycoside (not sure why its anti-parasitic, maybe kills parasite food)
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MOA of nitazoxanide
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interferes with pyruvate ferredoxin oxidoreductase (PFOR) e- transfer reactions
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DOC for non-HIV cryptosporidiosis
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nitazoxanide
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DOC for giardia
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any anti-parasitic
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drug of choice of trichomonas vaginalis
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metronidazole
tinidazole |
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antiparasitic drugs
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nitroimidazoles (metronidazole, tinidazole)
iodoquinol paromomycin nitazoxanide |
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antihelminthics drugs
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benzimidazoles (mebenazole, albendazole)
pyrantel pamoate ivermectin praziquantel |
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how does binding b-tubulin lead to death of worms
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decreases ATP and glucose production
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how does persistene activation of nicotinic receptors lead to death of worms
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depolarization blockade causes paralysis of worms
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causes subacute myelo-optic neuropathy (muscle pain, weakness, optic atrophy, and ataxia)
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iodoquinol
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MOA of paromomycin
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aminoglycoside (not sure why its anti-parasitic, maybe kills parasite food)
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MOA of nitazoxanide
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interferes with pyruvate ferredoxin oxidoreductase (PFOR) e- transfer reactions
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DOC for non-HIV cryptosporidiosis
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nitazoxanide
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DOC for giardia
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any anti-parasitic
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drug of choice of trichomoniasis
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metronidazole
tinidazole |
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how does binding to glutamate-gated Cl- channels cause death of worms (ivermectin)
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hyperpolarizes membrane and causes paralysis
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why are b-tubulin/nicotinic binding drugs selective to worms
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receptors are slightly different
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why are glutamate gated Cl- channel blockers selective to worms
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channel selective to invertebrates
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antihelminthic drug that causes CNS depression
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ivermectin
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how does ivermectin cause CNS depression
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if it crosses BBB (normally doesn't) it activates GABA receptors
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why does ivermectin normally not cause CNS depression
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doesn't cross BBB
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drugs used to tx roundworms in the gut
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mebendazole
albendazole pyrantel pamoate ivermectin |
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drugs used to roundworm in tissues
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albendazole
ivermectin |
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antihelminthic used in pregnancy
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pyrantel pamoate
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antihelminthic used in tx flukes (shistosoma)
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praziqunatel
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