Antineoplastics

Front 1

alkylating agent - attacks guaine N7

Back 1

Cyclophosphamide

Front 2

Hemorrhagic cystitis

Back 2

Cyclophosphamide

Front 3

Antidote for hemorrhagic cystitis and why?

Back 3

Mesna, traps acrolein

Front 4

Nephrotoxic

Back 4

Cisplatin, methotrexate

Front 5

Hepatotoxic

Back 5

6-MP, busulfan, cyclophosphamide

Front 6

Pulmonary toxicity

Back 6

bleomycin, busulfan, procarbazine

Front 7

Cardiotoxic

Back 7

Doxorubicin, daunorubicin

Front 8

Neurotoxic

Back 8

Vincristine, cisplatin, paclitaxel

Front 9

Immunosuppressive

Back 9

Cyclophosphamide, methotrexate

Front 10

Alkylating agent - cross-links DNA

Back 10

Cisplatin
Nitrosureas

Front 11

Major side effects of Cisplatin and their treatment

Back 11

Nausea, vomiting (use ondansetron)
Nephrotoxicity (use amifostine)
Neurotoxic= deafness

Front 12

Alkylating agent with pulmonary toxicity

Back 12

Procarbazine

other side effects = bone marrow suppression, hemolysis, neurotoxic, and leukemogenic

Front 13

Inhibits topoisomerase
Forms free radicals
Intercalator

Back 13

Doxorubicin

Front 14

Side effect of Doxorubicin and antidote

How does it work?

Other side effects.

Back 14

Delayed CHF (use dexrazoxane)

dexrazoxane prevents formation of free radicals

other side effects = alopecia, vescant, radiation "recall"

Front 15

Bone marrow suppression, mucositis, crystalluria

Back 15

Methotrexate

Use leucovorin for rescue (folinic acid)

Front 16

Inhibits DHF reductase

Back 16

Methotrexate (S phase)

Front 17

Inhibits thymidylate synthetase

Back 17

5-FU (pyrimidine antimetabolite)

Front 18

Used topically for basal cell and keratoses

Back 18

5-FU

Front 19

Treat acute lymphocytic leukemia

Back 19

6-Mercaptopurine, Vincristine, methotrexate

Front 20

Inhibits microtubules

Back 20

Vincristine, vinblastine

Front 21

Vincristine S/E

Back 21

Neurotoxic

Front 22

Vinblastine S/E

Back 22

Bone marrow suppression, GI, alopecia

Front 23

Most common reason for dose-limitation

Back 23

Bone marrow suppression

Front 24

Doesn't suppress bone marrow

Back 24

Cisplastin, bleomycin, vincristine

Front 25

Inhibits ribonucleotide reductase

Back 25

Hydroxyurea (results in decreased DNA synthesis)

Front 26

Anticancer drug also used for sickle cell anemia

Back 26

Hydroxyurea

also used for myeloproliferative disorders (CML, polycythemia vera) and melanoma

Front 27

Competitive inhibitor of tyrosine kinase

Back 27

Imatinib

Used in CML, GISTs & Brain tumors

Front 28

Monoclonal antibody against HER-2/neu

Back 28

Trastuzumab
(breast cancer)

Front 29

Binds tubulin and halts mitosis due to stabilization and polymerization of mitotic spindle

Back 29

Paclitaxel

M phase

Front 30

Inhibits topoisomerase II

Back 30

Etoposide

Front 31

Treats AML

Back 31

Cytarabine

Front 32

What metabolizes 6-MP

Back 32

xanthine oxidase

Front 33

Inhibits purine synthesis

Back 33

6-MP

Front 34

Forms free radicals, breaks DNA strands

Back 34

Bleomycin

Front 35

Nitrosureas

Back 35

Carmustine, lomustine, semustine, streptozocin

Alkylating agents that cross-link DNA strands

Front 36

Cross blood brain barrier, used to treat brain tumors

Back 36

Nitrosureas (carmustine)

Front 37

Patient with blisters on palms and soles and difficult to breath

Back 37

Bleomycin

Front 38

G2 Phase

Back 38

Bleomycin

Front 39

S Phase

Back 39

Cytarabine
6-MP
6-thioguanine
methotrexate
hydroxyurea
etoposide

Front 40

G0 Phase

Back 40

Alkylating agents (cyclophosphamide)
Nitrosureas
Cisplatin
Antitumor antibiotics

Front 41

M Phase

Back 41

Vinblastine
Vincristine
Paclitaxel

Front 42

Dexrazoxane

Back 42

Doxorubicin

Front 43

Mercaptoethanesulfonate

Back 43

(mesna) Cyclophosphamide

Front 44

Folinic acid

Back 44

(leucovorin) Methotrexate

Front 45

Cause of resistance to 6-MP

Back 45

Decrease activity of enzyme HGPRT. A purine salvage enzyme which activates 6-MP.