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15 Cards in this Set
- Front
- Back
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Two types of Drugs
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1.Act on a dividing cell
2.Act on a cell in any stage. |
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Cell cycle
1. G0 phase |
Non specific phase
-Alkylating agents -Antitumor antibodies -Nitrosurea -Dacarbazine -Ciplastin |
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2. G1 phase:
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Synthesis of cell components needed for DNA synthesis.
-L-asparginase -Mitomycin |
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3.S phase
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Cell cycle specific
-Period of DNA synthesis -Cytarabine -Methotrexate -Hydroxyurea -Etoposide -6-Mercaptopurine -6-Thioguanine |
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4.G2 Phase
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Preparation for Mitosis
-Bleomycin |
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5.M Phase
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Mitosis
-Vinblastine -Vincristine -Paclitaxel |
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1. Alkylating Agents
side effect wat do u give to prevent it? |
A. Nitrogen Mustard
Cyclophosphamide Ifosfamide -MOA--affect Guanine N7-non-functional DNA -side effect-Hemorrhagic Cysteine -to prevent it we give Mesna |
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B. Nitrosurea
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Lomustine: crosses BBB
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C. Platinum agents
Side effect? wat do u give to prevent it? |
Cisplastin
-Renal toxicity -Give Amifostine (cytoprotectant) |
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2. Antimetabolites
A. Purine analogs |
6-Mercaptopurine
-Inhibited by xanthine oxidase. reduced dose when given with Allopurinol. 6-Thioguanine |
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B. Pyrimidine Antagonist
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Inhibits thymidine synthetase.
5-Fluorouracil Flucytosine--Fungal cells Fluorouracil--cancer cells |
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C. Folate antagonist
-MOA -Antidote |
Methotrexate
-inhibits Dihydrofolate reductase -Levocurin in methotrexate toxicity |
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D. Hydroxurea
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Inhibits Ribonucleotide reductase.
-In low dose for treatment of Sickle Cell Anemia -Also for CML |
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3. Antibiotics
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A. Doxorubicin
B. Daunorubicin -Inhibits topoisomerase -risk of cytotoxicity--prevent with Dexrazoxane |
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C. Bleomycin
MOA side effects |
-Causes DNA strand excision.
-Pulmonary toxicity |
