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45 Cards in this Set
- Front
- Back
- 3rd side (hint)
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I....Alkylating Agents...
1. Nitrogen Mustards |
- Mechlorethamine
- Cyclophosphamide - Ifosfamide - Melphalan (L-phenylalanine mustard; L-PAM) - chiorambucil |
-Miscoding of DNA strands
-strand breaks or depurination -excessive cross-linking of DNA and an inability for strand separation at mitosis -not cell-cycle phase-special |
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2. alkyl sulfonate
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- Busulfan
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3. Nitrosoureas
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- Camustine
- Lomustine - semustine - streptozocin |
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4. other
1) triazene Derivative 2) Ethyleneimine Derivtive 3) Methylmelamine Derivative 4) Platinum Coordination Compounds |
1) Dacarbazine
2) Thiotepa 3) Altretamine 4) cisplatin; Carboplatin Procarbazine |
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II... Antimetabolites
1. folic Acid Analogs |
- Methotrexate (MTX)
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2. Pyrimidine Analogs
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- 5-fluorouracil (5-FU)
- Floxuridine (Fluorodeoxyuridine, FudR) - cytarabine (cytosine arabinoside, Ara-C) - Gemcitabine |
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3. Purine analogs
3' agents related to Purine Analogs |
3-1. 6-Mercaptopurine (6-MP)
3-2. 6- Thioguanine (6-TG) 3-3. Pentostatin (deoxycoformycin) 3-4. fludarabine 3-5. Cladribine 3'. Azathiioprine allopurinol |
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III....orther-1....
1. Plant Derivatives 2. Podophyllotoxins 3. Taxanes |
1.- Vincristine
- Vinblastine - vinorelbine 2.- etoposide (VP-16) - Teniposide (VP-28) 3. - Paclitaxel (Taxol) - Docetaxel |
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III....orther-2...
1 Antibiotics 2. Anthracycline Antibiotics |
1 - Dactinomycin (actinomycin-D)
2- Daunorubicin - Doxorubicin (adriamycin) - Idarubicin - Mitoxantrone - Plicamycin (mithramycin) - Mitomycin |
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III....orther-3 Hormonal Agents
1. Glucocorticoid 2. Progestins 3. Androgens 4. antiandrogens 5. Estrogens 6. Antiestrogens |
1.- Prednisons
2.- Hydroxyprogesterone - Medroxyprogesterone 3.- Fluoxymesterone - Testosterone 4.- Fluraminde -Bicalutmide - GnRH inhibitors Leuprolide Goserelin 5.- Ethinyl estradiol - Diethylstilbestrol (DES) - Estramustine 6.- Tamoxifen - Anastrozole - Aminoglutethimide 6.- |
5.-
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III....orther-4
Biologic response Modiflers |
- Inerferons (recombinant interferons alfa-2a, alfa-2b, alfa-n1, alfa-n3)
- Aldesleukin (recombinant interleukin-2, IL-2) |
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III....orther-5....
1. Miscellaneous Agents 2. Topoisomerase I inhibitors |
1.- L-Asparaginase
- Hydroxyurea - Mitotane 2. - Topotecan - Irinotecan |
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III....orther-6, Cell-Cycle
1. Nonspecific 2. Specific |
1. - Alkylating agents
- Antibiotics (except bleomycin) 2. - Antimetabolites - Vinca alkaloids - Bleomycin - Hydroxyurea |
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IV. Side Effects
1. Common 2. Unique |
1. - Bone marrow suppression
- Oral and gastrointestinal ulcers/stomatitis - Nausea & vomiting *** exceptions: . L-Asparaginase . Bleomycin . Vincristine . Hormonal agents |
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IV. Side Effects
2. Unique |
- Cyclophosphamide-hemorrhagic cystitis
- Vincristine-neurotoxicity - Cisplatin- nephrotoxicity - Daunorubicin- Cardiotoxicity - Doxorubicin-cardioitoxicity - Bleomycin- pulmonary toxicity - Plicamycin- hemorrhagic diathesis |
|
|
|
I....Alkylating Agents...
1. Nitrogen Mustards |
- Mechlorethamine
- Cyclophosphamide - Ifosfamide - Melphalan (L-phenylalanine mustard; L-PAM) - chiorambucil |
|
|
|
2. alkyl sulfonate
|
- Busulfan
|
|
|
|
3. Nitrosoureas
|
- Camustine
- Lomustine - semustine - streptozocin |
|
|
|
4. other
1) triazene Derivative 2) Ethyleneimine Derivtive 3) Methylmelamine Derivative 4) Platinum Coordination Compounds |
1) Dacarbazine
2) Thiotepa 3) Altretamine 4) cisplatin; Carboplatin Procarbazine |
|
|
|
II... Antimetabolites
1. folic Acid Analogs |
- Methotrexate (MTX)
|
|
|
|
2. Pyrimidine Analogs
|
- 5-fluorouracil (5-FU)
- Floxuridine (Fluorodeoxyuridine, FudR) - cytarabine (cytosine arabinoside, Ara-C) - Gemcitabine |
|
|
|
3. Purine analogs
3' agents related to Purine Analogs |
3-1. 6-Mercaptopurine (6-MP)
3-2. 6- Thioguanine (6-TG) 3-3. Pentostatin (deoxycoformycin) 3-4. fludarabine 3-5. Cladribine 3'. Azathiioprine allopurinol |
|
|
|
III....orther-1....
1. Plant Derivatives 2. Podophyllotoxins 3. Taxanes |
1.- Vincristine
- Vinblastine - vinorelbine 2.- etoposide (VP-16) - Teniposide (VP-28) 3. - Paclitaxel (Taxol) - Docetaxel |
|
|
|
III....orther-2...
1 Antibiotics 2. Anthracycline Antibiotics |
1 - Dactinomycin (actinomycin-D)
2- Daunorubicin - Doxorubicin (adriamycin) - Idarubicin - Mitoxantrone - Plicamycin (mithramycin) - Mitomycin |
|
|
|
III....orther-3 Hormonal Agents
1. Glucocorticoid 2. Progestins 3. Androgens 4. antiandrogens 5. Estrogens 6. Antiestrogens |
1.- Prednisons
2.- Hydroxyprogesterone - Medroxyprogesterone 3.- Fluoxymesterone - Testosterone 4.- Fluraminde -Bicalutmide - GnRH inhibitors Leuprolide Goserelin 5.- Ethinyl estradiol - Diethylstilbestrol (DES) - Estramustine 6.- Tamoxifen - Anastrozole - Aminoglutethimide 6.- |
5.-
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|
|
III....orther-4
Biologic response Modiflers |
- Inerferons (recombinant interferons alfa-2a, alfa-2b, alfa-n1, alfa-n3)
- Aldesleukin (recombinant interleukin-2, IL-2) |
|
|
|
III....orther-5....
1. Miscellaneous Agents 2. Topoisomerase I inhibitors |
1.- L-Asparaginase
- Hydroxyurea - Mitotane 2. - Topotecan - Irinotecan |
|
|
|
III....orther-6, Cell-Cycle
1. Nonspecific 2. Specific |
1. - Alkylating agents
- Antibiotics (except bleomycin) 2. - Antimetabolites - Vinca alkaloids - Bleomycin - Hydroxyurea |
|
|
|
IV. Side Effects
1. Common 2. Unique |
1. - Bone marrow suppression
- Oral and gastrointestinal ulcers/stomatitis - Nausea & vomiting *** exceptions: . L-Asparaginase . Bleomycin . Vincristine . Hormonal agents |
|
|
|
IV. Side Effects
2. Unique |
- Cyclophosphamide-hemorrhagic cystitis
- Vincristine-neurotoxicity - Cisplatin- nephrotoxicity - Daunorubicin- Cardiotoxicity - Doxorubicin-cardioitoxicity - Bleomycin- pulmonary toxicity - Plicamycin- hemorrhagic diathesis |
|
|
|
I....Alkylating Agents...
1. Nitrogen Mustards |
- Mechlorethamine
- Cyclophosphamide - Ifosfamide - Melphalan (L-phenylalanine mustard; L-PAM) - chiorambucil |
|
|
|
2. alkyl sulfonate
|
- Busulfan
|
|
|
|
3. Nitrosoureas
|
- Camustine
- Lomustine - semustine - streptozocin |
|
|
|
4. other
1) triazene Derivative 2) Ethyleneimine Derivtive 3) Methylmelamine Derivative 4) Platinum Coordination Compounds |
1) Dacarbazine
2) Thiotepa 3) Altretamine 4) cisplatin; Carboplatin Procarbazine |
|
|
|
II... Antimetabolites
1. folic Acid Analogs |
- Methotrexate (MTX)
|
|
|
|
2. Pyrimidine Analogs
|
- 5-fluorouracil (5-FU)
- Floxuridine (Fluorodeoxyuridine, FudR) - cytarabine (cytosine arabinoside, Ara-C) - Gemcitabine |
|
|
|
3. Purine analogs
3' agents related to Purine Analogs |
3-1. 6-Mercaptopurine (6-MP)
3-2. 6- Thioguanine (6-TG) 3-3. Pentostatin (deoxycoformycin) 3-4. fludarabine 3-5. Cladribine 3'. Azathiioprine allopurinol |
|
|
|
III....orther-1....
1. Plant Derivatives 2. Podophyllotoxins 3. Taxanes |
1.- Vincristine
- Vinblastine - vinorelbine 2.- etoposide (VP-16) - Teniposide (VP-28) 3. - Paclitaxel (Taxol) - Docetaxel |
|
|
|
III....orther-2...
1 Antibiotics 2. Anthracycline Antibiotics |
1 - Dactinomycin (actinomycin-D)
2- Daunorubicin - Doxorubicin (adriamycin) - Idarubicin - Mitoxantrone - Plicamycin (mithramycin) - Mitomycin |
|
|
|
III....orther-3 Hormonal Agents
1. Glucocorticoid 2. Progestins 3. Androgens 4. antiandrogens 5. Estrogens 6. Antiestrogens |
1.- Prednisons
2.- Hydroxyprogesterone - Medroxyprogesterone 3.- Fluoxymesterone - Testosterone 4.- Fluraminde -Bicalutmide - GnRH inhibitors Leuprolide Goserelin 5.- Ethinyl estradiol - Diethylstilbestrol (DES) - Estramustine 6.- Tamoxifen - Anastrozole - Aminoglutethimide 6.- |
5.-
|
|
|
III....orther-4
Biologic response Modiflers |
- Inerferons (recombinant interferons alfa-2a, alfa-2b, alfa-n1, alfa-n3)
- Aldesleukin (recombinant interleukin-2, IL-2) |
|
|
|
III....orther-5....
1. Miscellaneous Agents 2. Topoisomerase I inhibitors |
1.- L-Asparaginase
- Hydroxyurea - Mitotane 2. - Topotecan - Irinotecan |
|
|
|
III....orther-6, Cell-Cycle
1. Nonspecific 2. Specific |
1. - Alkylating agents
- Antibiotics (except bleomycin) 2. - Antimetabolites - Vinca alkaloids - Bleomycin - Hydroxyurea |
|
|
|
IV. Side Effects
1. Common 2. Unique |
1. - Bone marrow suppression
- Oral and gastrointestinal ulcers/stomatitis - Nausea & vomiting *** exceptions: . L-Asparaginase . Bleomycin . Vincristine . Hormonal agents |
|
|
|
IV. Side Effects
2. Unique |
- Cyclophosphamide-hemorrhagic cystitis
- Vincristine-neurotoxicity - Cisplatin- nephrotoxicity - Daunorubicin- Cardiotoxicity - Doxorubicin-cardioitoxicity - Bleomycin- pulmonary toxicity - Plicamycin- hemorrhagic diathesis |
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