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13 Cards in this Set
- Front
- Back
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Side Effects of Sulfonamindes
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Crystalluria
KCS Hepatic necrosis Blood dyscrasias (hypoprotothrombinemia, anemia, thrombocytopenia) Dogs- Thyroid metabolic disorders Skin reactions, e.g. dermatitis (Potentiated Sulfas) Possibly carcinogenic |
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Side Effects of Fluoroquinolones
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Cats-retinal degeneration
Seizures Young animals (including fetus)- arthropathy and cartilage defects GI disturbances |
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Side Effects of Lincosamides
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GI upset, particularly in hind-gut fermenters (horses, rabbits)- can cause enterocolitis and lead to death (pseudomembranous colitis); overgrowth of Clostridium bacteria
Dairy cattle- ketosis Hypersensitivity |
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Side Effects of Macrolides
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Inhibits Cyt P450
Foal hyperthermia with diarrhea and respiratory distress Vomiting, diarrhea (especially in horses) Erythromycin is GI prokinetic |
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Side Effects of Tetracyclines
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Bacterial overgrowth (can cause enteritis in horses)
Esophageal lesions (esp. from lodging of pill in esophagus) Young animals- bone discoloration and can cause abnormal development of long bones in the fetus Renal tubular necrosis Photosensitivity Hepatic disease (idiosyncratic) Allergies IV administration- cardiovascular collapse (rate-related) |
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Side Effects of Chloramphenicol
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Inhibit Cyt P450
Aplastic anemia in humans (illegal for use in food animals) Dogs- bone marrow suppression Cats- metabolized by glucuronidase, so can build up toxicity |
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Side Effects of Florfenicol
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Mild bone marrow suppression
Diarrhea Cattle- GI disturbances (anorexia, diarrhea); injection site reactions |
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Side Effects of Aminoglycocides
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Ototoxicity
Nephrotoxicity (especially Neomycin) Neuromuscular blockade |
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Side Effects of Penicillins
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Allergies
Disrupts intestinal bacteria (Clostridium overgrowth) CNS reactions (uncommon) |
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Side Effects of Aminopenicillins
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Contraindicated in hind-gut fermenters (horses, rabbits, etc.)
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Side Effects of Cephalosporins
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Blood dyscrasias in humans, some in animals (phlebitis, thrombocytopenia)
Hypersensitivity Some acute GI effects (vomiting, etc.)- irritation to mucosa |
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Side Effects of Cerbepenems
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Seizures
Renal injury (less with meropenem) |
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Side Effects of Metronidazole
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Hepatotoxicity
Neurological disorders, lethargy GI effects Cats- sensitive to benzoic acid toxicity (more palatable formation) Carcinogenic in people |
