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20 Cards in this Set
- Front
- Back
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Which antifungal treats a wide range of systemic mycoses but causes fever & chills, renal tox, hypotension, and arrhythmias?
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Amphotericin B - binds ergosterol and punches holes in membrane
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Which antifungal is for topical use only because it is too toxic to ingest? For oral thrush, yeast infection, diaper rash.
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Nystatin - binds ergosterol
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What do you give an AIDS patient with cryptococcal meningitis?
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Fluconazole - also good for candida infections of all types
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Which antifungal is used for systemic mycoses as well as hypercortisolism?
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Ketoconazole - inhibits desmolase, my favorite enzyme
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Which antifungal can cause gynectomastia, fever, chills, and inhibits P450?
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Ketoconazole
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Which antifungal inhibits DNA synthesis by competing with uracil?
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Flucytosine - Candida, Cryptococcus
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What do you give a patient with invasive Aspergillosis?
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Caspofungin - inhibits cell wall synthesis, causes GI upset and flushing
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Which antifungal is used for nail fungal infections?
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Terbinafine - inhibits squalene epoxidase in ergosterol pathway
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Which antifungal is good for ringworm but contraindicated in pregnancy?
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Griseofulvin - inhibit microtubles, for superficial infections
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Which antifungal can increase warfarin metabolism?
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Griseofulvin
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What are 2 clinical uses of Amantadine?
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- influenza A
- Parkinson's disease |
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What are 2 neuraminidase inhibitors?
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- Oseltamivir
- Zanamivir * for influenza A & B |
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What can you give your infant patient who has RSV, and also your IVDU patient with chronic HCV?
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Ribavirin
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Ribavirin is contraindicated in:
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pregnancy - severe teratogen (also causes hemolytic anemia)
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What do you give a patient wtih HSV, VZV, or EBV?
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Acyclovir - inhibits viral DNA polymerase
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Your patient has AIDS and a CMV infection. What do you give him?
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Gancyclovir - inhibits CMV DNA polymerase
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What are serious side effects of Gancyclovir? (4)
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leukopenia, neutropenia, thrombocytopenia, and renal toxicity
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If Gancyclovir doesn't seem to work for your AIDS patient with CMV, what else can you try?
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Foscarnet - CMV retinitis in AIDS, or acyclovir-resistant HSV (inhibits DNA polymerase)
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What are side effects of protease inhibitors?
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- nausea, diarrhea
- hyperglycemia - fat abnormalities - thrombocytopenia (indinavir) |
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What are some examples of reverse transcription inhibitors that work via nucleosides?
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- Zidovudine (AZT)
- didanosine (ddI) - stavudine (d4T) - lamivudine (3TC) - abacavir |
