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11 Cards in this Set
- Front
- Back
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MTX inhibits |
DHFR which makes THF |
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Florouracil |
Instead of dUMP AND INHIBITS THYMIDILATE SYNTHASE Prodrug |
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Metabolized by DPD, which African Americans mostly women are deficient (toxicity) |
Fluorouracil |
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Capecitabine (Xeloda) |
5FDump prodrug PO First line colorectal cancer Tumor selective (Thymidine phosphorylase) in activation |
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Competes for DHFR enzyme against DHF, indirectly feedback inhibits TS (rate limiting step enzyme) Also inhibits purine synthesis brought GAR inhibition |
Trexall, MTX |
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Purine antagonist inhibitor of |
Amidophosphoribosyl transferase (rate limiting!!) AGR TRANSFORMYLASEinhibited by MTX AND permetrxed |
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TPMT and SAM |
Cause inactive substrate Poor metabolized is bad —>active pathway toxic myelosupression |
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Inhibit AMIDOPHOSPHORIBOSYL TRANSFERSASE (rle) Bone marrow suppression!! |
Mercaptopurine |
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Cytarabine/ gemticibine All the -bines |
Dna chain elongation inhibitors |
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Dna methyltransfrase inhibitors |
Aza, is dec,nel |
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Adenosine deaminase inhibitor |
Pentostatine |
