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29 Cards in this Set
- Front
- Back
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eliminates hypnozoites but has no effect on erythrocyte stages of the malarial cycle
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primaquine
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cause of acute hemolytic anemia assx with primaquine
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G6PD deficiency
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patient population at risk for acute hemolytic anemia with primaquine
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pregnant women and newborns
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drugs that can cause hemolytic anemia
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primaquine
chloroquine quinine pyrimethamine (high dose) |
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basis of the selective toxicity of chloroquine and pyrimethamine for malaria parasite
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actively concentrate in parasitized erythrocyte
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agents that tx CQ resistant acute malaria attacks
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quinine +
doxycycline or tetracycline or clindamycin |
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antimalarial agents that can cause cardiac problems
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chloroquine
mefloquine quinine |
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used to tx severe or complicated infections of P. falciparum
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quinine
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what drug is used to tx severe or complicated falciparum infections, along with quinine, in children
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clindamycin
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agent that can cause cinchonism
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Quinine
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clinical signs of cinchonism
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tinnitus, headache, nausea, dizziness, visual changes
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agents that inhibits dihydrofolate reductase
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proguanil
pyrimethamine |
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agents used in combination preparations for emergency presumptive self-tx of malaria
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pyrimethamine + sulfadoxine
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why are atovaquone and proguanil used in combination
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atovaquone: inhibits e- transport
proguanil: DHFR inhibitor |
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broad spectrum antibiotic used in malaria tx
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doxycycline
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agents used for chemoprophylaxis of malaria in CQ-resistant areas
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mefloquine
doxycycline atovaquone + proguanil |
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agents used for chemoprophylaxis in mefloquine-resistant areas
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doxycycline or atovaquone + proguanil
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DOC for eradication of dormant liver forms of P vivax and P ovale
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primaquine
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three classes of antimalarial drugs
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tissue schizonticides
blood schizonticides gametocides |
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clinical use of primaquine
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terminal prophylaxis
radical cure |
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DOC for chemoprophylaxis and acute attacks
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chloroquine
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MOA of chloroquine
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binds heme and prevents polymerization
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side effects of mefloquine
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neuropsychiatric effects
CV (CI in pt taking b blocks or CCBs) |
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name of quinine in the US
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quinidine IV
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DOC for uncomplicated CQ-resistant strains
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quinine
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side effects of quinine
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QT prolongation
Blackwater fever (massive hemolysis) curare-life effect (myasthenia gravis sx) oxytocic (induces labor) acute hemolysis cinchonism hypoglycemia |
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pyrimethamine is used in combination with what
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sulfadoxine
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why is pyrimethamine used with sulfadoxine
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sequential inhibition of folate synthesis (retards resistance emergence)
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contraindications for doxycyline
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children
pregnant women |
