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5 Cards in this Set
- Front
- Back
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HMG-CoA Reductase Inhibitors:
-STATINS |
Lower LDL
blocks 1st step in cholesterol synthesis; incr LDL receptors on hepatocyts; decr VLDL Elevate liver enzymes (ALT); myopathy and rhabdomyolysis CONTRAINDICATED IN PREGNANCY |
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FIBRATES:
CloFIBRate FenoFIBRate GemFIBRozil |
Lower serum TRIGLYCERIDES, LDL; incr HDL
Type III (Dysbetalipoproteinemia), and IV & V PPARa Myopathy GI symptoms Cholelithiasis Compete for Hepatic Enzymes Well absorbed when taken with food. Highly protein bound. Will displace warfarin and other highly protein bound drugs when taken concomitantly Gemfibrozil inhibits hepatic uptake of HMG-CoA Reductase Inhibitors CONTRAINDICATED IN PREGNANCY AND LIVER DISEASE |
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NIACIN VIT B3
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Significantly increases HDL. lowers rest
Types II-V Flushing (prostaglandin mediated) Pruritis (itching) Impaired Glucose Metabolism (contraindicated in Diabetes Mellitus) Hyperuricemia and gout GI side effects Hepatotoxicity Avoid use in Pregnancy |
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BILE ACID SEQUESTRANTS:
COLEstipol CHOLEstyramine COLEsevelam |
Inhibit reabsorption of bile salts.
Induce the conversion of cholesterol to bile salts rather than VLDL production Induces synthesis of LDL receptors and removal of LDL from circulation GI symptoms- constipation, flatulence, nausea Impaired absorption of vit. A,D,E,K Impaired absorption of Warfarin, Tetracycline, Digoxin, Phenobarbital, Statins |
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EZETIMIBE
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Cholesterol absorption inhibitor
Mild decrease in cholesterol, LDL, triglycerides Undergoes phase II conjugation Avoid in patients with hepatic dysfunction |
