Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
29 Cards in this Set
- Front
- Back
|
Statins MOA
|
HMG-CoA Reductase inhibitors slow the rate limiting step in production of cholesterol
|
|
|
Statins
|
Lova-statin
Simva- Atorva- Fluva- Prava- Pitava- Rosuva- |
|
|
Statins effects
|
Up regulates LDL receptors, increasing cholesterol metabolism
|
|
|
Statins AEs
|
1. Liver and muscle toxicity
2. elevated AST/ALT |
|
|
Statins contraindications
|
Liver, renal failure
Pregnancy (X) |
|
|
Statins interactions
|
CYP 3A4/2C9 inhibitors
|
|
|
Bile Acid Sequestrants
|
Cholestyramine
Colesevelam Colestipol |
|
|
Bile Acid Seq effects
|
Reduces LDL
May increase TG |
|
|
Bile Acid Seq MOA
|
Bind bile acid in intestinal lumen, resulting in upreg of LDLr and 7-alpha hydroxylase (synth bile acids from cholesterol
|
|
|
Bile Acid Seq AE
|
GI - constipation
increased liver enzymes Hypoprothrombinemia (Vit K) |
|
|
Bile Acid Seq interactions
|
Extensive, admin at different times
|
|
|
Bile Acid Seq contraind
|
Hyper TG
Constipation Bleeding Pregnancy (C) |
|
|
Cholesterol Absorbtion Inhibitors
|
Ezetimibe
Vytorin - Ezetimibe + Simvastin |
|
|
Cholesterol Absorbtion Inhibitors effects
|
Rarely used alone
Reduces delivery of cholesterol to liver |
|
|
Cholesterol Absorbtion Inhibitors MOA
|
Inhibits absorbtion of cholesterol and Phytosterols at brush border of small intestine
|
|
|
Cholesterol Absorbtion Inhibitors AE
|
GI - diarrhea, ab pain etc
|
|
|
Cholesterol Absorbtion Inhibitors interactions
|
none significant
|
|
|
Cholesterol Absorbtion Inhibitors contraindications
|
sever hepatic disease
Pregnancy (C) |
|
|
Fibrates
|
PPAR-alpha activators:
Fenofibrate (p) Gemfibrozil |
|
|
Fibrates effects
|
Greatest reduction of TG
|
|
|
Fibrates MOA
|
Activates Peroxisome Proliferator Activated Receptors, thereby increasing catabolism of VLDL/IDL
Also decr hepatic FFA excr |
|
|
Fibrates AE
|
Liver/muscle - careful when combining with a statin
Predisposing to gallstones |
|
|
Fibrates interactions
|
Increases effects of anti-hyperglyscemic agents
|
|
|
Fibrates contraind
|
severe renal or hepatic disease
biliary cirrhosis/cholelithiasis Pregnancy (C) |
|
|
Niacin (B3) effects
|
increased HDL via decr catabolism
increased LDLr activity |
|
|
Niacin (B3) MOA
|
Reduces hepatic synth of TG, VLDL & LDL
|
|
|
Niacin (B3) AE
|
1 cutaneous flushing
2 incr serum glucose 3 incr uremic acid |
|
|
Niacin (B3) interactions
|
no significant
|
|
|
Niacin (B3) contra
|
chronic liver/GB
severe gout diabetes PUD bleeding/warfarin |
