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11 Cards in this Set
- Front
- Back
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Nicotinic acid (Niacin as nicotinic acid)
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Reduced total serum cholesterol, LDL, VLDL, and triglycerides and inclreases HDL
Decreased hepatic synthesis and lipolysis Vasodilation, "niacin-flush," increased histamine secretion, gastric motility |
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Cholestyramine (Questran)
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Bile acid sequestering resin
Interferes with bile acid reuptake, increases cholesterol production and intensifies uptake of LDL May trap other medications, administer at different time Side Effects: constipation, impaction, coagulopathy (binds Vit K), phenylketonuria |
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Colestipol (Cholestid)
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Bile acid sequestering resin
May trap other medications, administer at different time Side Effects: constipation, impaction, coagulopathy (binds Vit K), phenylketonuria |
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Colesevelam (WelChol)
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Bile acid sequestering resin
Less potential to reduce drug bioavailability than Colestipol (Cholestid) and Cholestyramine (Questran) |
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HMG-CoA reductase inhibitors
Competes with enzyme and interferes with process of cholesterol production |
Lovastatin (Mevacor)
Atorvastatin (Lipitor) Fluvastatin (Lescol) Prevastatin (Pravachol) Simvastatin (Zocor) Rosuvastatin (Crestor) |
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Lovastatin (Mevacor)
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HMG CoA reductase inhibitor
Side effects: Toxicity to skeletal muscle, rhabdomyolysis with renal dysfuction, elevation in transaminasis (check SGOT and SGPT) Category X, do not take in hepatic disease |
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Fibric acid derivatives
Reduce serum triglycerides and cholesterol |
Gemfibrozil (Lopid)
Clofibrate (Atromid-S) Finofibrate (Tricor) |
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Gemfibrozil (Lopid)
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Fibric acid derivative
Inhibits lipolysis, decreases hepatic triglyceride production, inhibits synthesis and increases clearance of apolipoprotein B (carrier of VLDL) |
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Clofibrate (Atromid-S)
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Fibric acid derivative
Seldom used, not shown to reduce cardiovascular events, increases in non cardiovascular events |
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Finofibrate (Tricor, Lofibra)
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Fibric acid derivative
Induces lopoprotein lipase and decreases production of apolipoprotein CIII via peroxisome proliferator activated receptors (PPARs), enhances fatty acid oxidation |
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Ezetimibe (Zetia)
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Cholesterol absorption inhibitor
Blocks intestinal absorption by small intestine, complementary to HMG-CoA reductase inhibitors |
