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22 Cards in this Set
- Front
- Back
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Statin Efffects
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Dec LDL
Dec VLDL Dec Thrombus Inc Plaque Stability Inc endothelial function Dec inflammation Dec. oxygen stress |
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Statin MOA
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HMG-CoA Reductase Inh
Main drop is from LDL Clearance (now used to make cholesterol) Transported through OATs |
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Atorvastatin A/E
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Skeletal muscle toxicity
Hepatotoxicity Increase likelihood of Diabetes Inc K+ Inc myoglobin (renal damage) |
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Atorvastatin Metabolism
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CYP3A4
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Simvastatin Differences
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More hydrophobic
More extra-hepatic effects |
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Simvastatin Metabolism
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CYP3A4
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Rosuvastatin Differences
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More hydrophobic
More Extra-hepatic efffects More effect on LDLs Genfibrozil increases blood levels |
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Rosuvastatin Metabolism
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Biliary excretion
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Colesevelam Drug Type
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Anti-hyperlipidemic
Sequestrin |
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Colesevelam MOA
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Polymer & anion exchange resin
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Colesevelam Effects
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Dec LDL
Can inc VLDL Dec glysolyated Hb in T2D |
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Colesevelam A/E
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GI (fewer than most)
Dec fat sol vitamins Dec neg charged or lipid sol drugs |
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Ezetimibe Drug Type and MOA
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Antihyperlipidemic
Blocks NPC1L1 cholesterol transport |
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Ezetimibe Effects & combo med
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Dec LDL
Dec atherosclerotic thickening Statin combo |
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Ezetimibe A/E
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Hepatotoxicity
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Ezetimibe metabolism
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Glucuronidated
Enterohepatic recycling |
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Nicotinic Acid MOA & Effects
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Inc HDL
Dec VLDL Adipocyte receptor (GPR109A) inhibits HSL activation by beta receptors and protein kinase A |
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Nicotinic Acid A/E
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GI
Flushing Dec insulin sensitivity Hyperuricemia Hepatotoxicity |
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Fenofibrate Drug Type & MOA
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Antihyperlipidemic
PPAR-alpha agonist |
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Fenofibrate Effects
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Inc HDL
Dec VLDL Inc oxidation of FA in liver Dec synth of apoCIII in liver Skeletal muscle inc LPL Dec neuropathy and retinopathy in T2D |
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Fenofibrate A/E
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Cholelithiasis
Venous thrombosis Pulmonary embolism Myopathy |
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Fenofibrate Metabolism
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Hepatic
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