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15 Cards in this Set
- Front
- Back
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What is the action of histamine?
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Vasodilation
Increases capillary permeability Bronchoconstriction Secretion of Acid in the Stomach Neurotransmitter |
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Where is histamine found in the body?
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Mast cells and Basophils
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___ are mediated by histamine.
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Allergic reactions
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Histamine plays a large role in anaphylactic shock.
T or F |
False
Minor Role |
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What are the classic antihistamines?
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H1 antagonists
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What is the difference between the first and second generation antihistamines?
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First generation is highly sedating; Second generation is not
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Where do most of the side effects of histamine come from?
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Ability of antihistamines to bind to and block muscarinic receptors
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What are the effects of a H1 antihistamine?
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Reduce inflammation
Reduce edema Reduce itching and pain Suppress secretion of mucus |
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At therapeutic doses antihistamines cause CNS _____, while an overdose causes CNS _____.
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Depression
Stimulation |
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What are some of the adverse effects of antihistamines?
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GI effects
Anticholinergic effects |
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What are some drug interactions with antihistamines?
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CNS Depressants
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Which first generation antihistamine causes the least amount of CNS Depression?
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Chlorpheniramine
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What is a very common antihistamine?
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Diphenhydramine
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What are the second generation antihistamines?
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azelastine
cetirizine fexofenadine loratadine |
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What is unique about azelatine?
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Nasal spray
Blocks the release of histamine |
