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15 Cards in this Set

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  • Back
What is the action of histamine?
Vasodilation
Increases capillary permeability
Bronchoconstriction
Secretion of Acid in the Stomach
Neurotransmitter
Where is histamine found in the body?
Mast cells and Basophils
___ are mediated by histamine.
Allergic reactions
Histamine plays a large role in anaphylactic shock.
T or F
False
Minor Role
What are the classic antihistamines?
H1 antagonists
What is the difference between the first and second generation antihistamines?
First generation is highly sedating; Second generation is not
Where do most of the side effects of histamine come from?
Ability of antihistamines to bind to and block muscarinic receptors
What are the effects of a H1 antihistamine?
Reduce inflammation
Reduce edema
Reduce itching and pain
Suppress secretion of mucus
At therapeutic doses antihistamines cause CNS _____, while an overdose causes CNS _____.
Depression
Stimulation
What are some of the adverse effects of antihistamines?
GI effects
Anticholinergic effects
What are some drug interactions with antihistamines?
CNS Depressants
Which first generation antihistamine causes the least amount of CNS Depression?
Chlorpheniramine
What is a very common antihistamine?
Diphenhydramine
What are the second generation antihistamines?
azelastine
cetirizine
fexofenadine
loratadine
What is unique about azelatine?
Nasal spray
Blocks the release of histamine