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15 Cards in this Set

  • Front
  • Back
mast cells are in which tissues?
respiratory tract, GI, skin
where are histamine release from?
secretory granules (in response to a stimulus) --> IgE
what decreases GI toxicity?
ethanolamine - diphenhydramine
what 2 increase sedation, and which class are they?
1st gen - hydroxyzine
2nd gen - cetirizine (metabolite)
both are piperazine
anti-serotonergic class?
piperidine, cyproheptadine
what 2nd generation undergoes some P450 metabolism?
fexofenadine (from terfenadine)
which has no cardiac effects?
piperadine - Loratadine
what are the 2 piperadines?
cyproheptadine
Loratadine
effects of H1?
bronchoconstriction (of smooth muscles)
vasodilation (of endo cells)
wakefulness (brain)
itching
what has increase cAMP?

what has decreased cAMP?
H2

H3
post-synaptic H?
H1, H2
presynaptic H?
H3
effects of H1 (1st gen)
muscarinic effects (dry mouth, urinary retention0
penetrates CNS
sedation
shorter t1/2
effects of H1 on CNS/hypothalamus?
inc. wakefulness
itching, pain regulation
effects of H1/H2?
body temp
drinking H20
ADH secretion