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15 Cards in this Set
- Front
- Back
mast cells are in which tissues?
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respiratory tract, GI, skin
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where are histamine release from?
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secretory granules (in response to a stimulus) --> IgE
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what decreases GI toxicity?
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ethanolamine - diphenhydramine
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what 2 increase sedation, and which class are they?
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1st gen - hydroxyzine
2nd gen - cetirizine (metabolite) both are piperazine |
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anti-serotonergic class?
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piperidine, cyproheptadine
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what 2nd generation undergoes some P450 metabolism?
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fexofenadine (from terfenadine)
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which has no cardiac effects?
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piperadine - Loratadine
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what are the 2 piperadines?
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cyproheptadine
Loratadine |
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effects of H1?
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bronchoconstriction (of smooth muscles)
vasodilation (of endo cells) wakefulness (brain) itching |
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what has increase cAMP?
what has decreased cAMP? |
H2
H3 |
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post-synaptic H?
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H1, H2
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presynaptic H?
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H3
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effects of H1 (1st gen)
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muscarinic effects (dry mouth, urinary retention0
penetrates CNS sedation shorter t1/2 |
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effects of H1 on CNS/hypothalamus?
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inc. wakefulness
itching, pain regulation |
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effects of H1/H2?
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body temp
drinking H20 ADH secretion |