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14 Cards in this Set
- Front
- Back
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What type of crystals are deposited in joints to cause gouty arthritis.
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Monosodium urate crystals.
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What are the manifestations of hyperuricemia.
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Gouty nephropathy
Obstuctive nephropathy Nephrolithiasis. |
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What common metabolic disorder is known to cause hyperuricemia
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Diabetes Mellitus
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Which drugs are known for causing hyperuricemia?
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Asipirin, diuretics, ehtambutal, L-dopa, cyclosporin, alcohol, nicotine.
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What tow enzymes are involved in the genetic cause of hyperuricemia?
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HGPRT and PRPP synthetase.
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Colchicine
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Antigout drug. Binds to tubulin and prevents polymerization into microtubules. Inhibits migration of phagocytes and leukocytes.
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Indomethacin
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Inhibits PG synthetase and inhibits urate crystal phagocytosis.
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Probenecid
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Inhibits uric acid reabsorption and decreases serum urate concentration.
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Sulfinpyrazone
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Inhibts urica acid reabsorption, decreases serum urate concentration.
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What are the toxic effects of sulfinpyrazone?
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GI irritation and hypersensitivity skin reaction.
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Allopurinol
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Decreases uric acid production by inhibiting xanthin oxidase and decreasing intracellular concentrations of PRPP.
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What are the therapuetic uses of allopurinol?
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Treats gouty nephropathy, tophaceous gout, and renal urate stones.
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Which drugs have adverse reactions with allopurinol?
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6-MP, azathioprine, oral anticoagulants, ampicillin.
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Febuxostat
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Nonpurine inhibitor of xanthine oxidase.
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