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13 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Macrolide Polyenes |
Amphotericin Natamycin Nystatin |
Macrolide Polyenes Bind to fungal membranes causing loss of selective permeability; extemely versitile Can be used to treat skin mucous membrane lesions caused by Candida albicans; injectable form can be used to treat histoplasmosis and Cryptococcus meningitis |
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Natamycin |
Used for treatment of fungal keratitis |
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Nystatin |
used in treatment of Candida and Cryptococcus infection |
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Azoles |
Imidazoles: ketoconazole, clotrimazole, miconazole Triazoles: fluconazole, itraconazole, variconazole Thiazoles: abafungin |
Interfere with sterole synthesis in fungi |
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Ketoconazole |
Cutaneous mycoses, vaginal and oral candidiasis, systemic mycoses |
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Fluconazole |
used to treat AIDS related mycoses
(aspergillosis, cryptococcus meningitis) |
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Clotrimazole and Miconazole |
used to treat infection in the skin mouth and vagina |
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Abafungin |
synthetic antifungal drug thta targes both dividing and undividing cells |
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Echinocandins |
Micafungin caspofungin Anidulafungin |
inhibit fungal cell wall synthesis useful in immunocompromised patients used against candida strains and aspergillosis |
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Allylamines |
Terbinafine (Lamisil) |
Block sterol synthesis in fungi Highly liphiilic making them useful in the treatment of dermatophytic infections |
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Miscellaneous Anti-fungals |
Griseofulvin Flucytosine |
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Griseofulvin |
Inhibits microtubule function in fungi Use in oral form for dermatopytic infections |
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Flucytosine |
Rapidly absorbed orally, readily dissolves in the blood and CSF Used to tret cutaneous mycoses Usually combined with amphotericin B to treat systemic mycoses because many fungi are resistant to this drug, |
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