Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
15 Cards in this Set
- Front
- Back
|
Nystatin |
Class: polyene PK: topical Use: oral thrush (swish and swallow) |
|
|
Amphotericin B |
Class: polyene PK: IV MOA: binds ergosterol Use: broad spectrum antifungal, severe infection Adverse effects: nephrotoxicity, infusion related toxicity (cytokine storm) - give NSAIDs |
|
|
Ketoconazole |
Class: imidazole PK: topical MOA: CYP450 inhibitor - 14alpha demthylase enzyme Use: broad spectrum Adverse effect: drug interactions |
|
|
Clotrimazole |
Class: imidazole PK: topical Use: jock itch, athletes foot, yeast infection, ring worm |
|
|
Miconazole |
Class: imidazole PK: topical Use: yeast infection and dermatophyte infections |
|
|
Itraconazole |
Class: triazole PK: PO Use: histoplasmosis, blastomyces, sporotrichosis Adverse effect: CHF |
|
|
Fluconazole |
Class: triazole PK: oral and IV Use: systemic candidiasis, cryptococcal meningitis, coccidioidal meningitis |
|
|
Voriconazole |
Class: triazole PK: oral and IV Use: aspergillosis Adverse effects: visual disturbance, hepatic toxicity |
|
|
Pasoconazole |
Class: triazole PK: oral and IV Use: mucormycosis, highest spectrum |
|
|
Caspofungin |
Class: echinocandin PK: IV MOA: disrupts cell wall Use: empirical treatment for candida, second line for aspergillosis Adverse effect: GI effects, infusion reaction |
|
|
Micafungin |
Class: echinocandin |
|
|
Terbinafine |
Class: allylamine MOA: inhibits squalene epoxidase - disrupts cell membrane PK: oral/topical Use: dermatophyte infection Adverse effects: hepatotoxic, Stevens-Johnson syndrome, neutropenia |
|
|
Flutycytosine |
Class: pyrimidine analog PK: Oral MOA: disrupts thymidylate synthesis Use: adjunct treatment for cryptococcal meningitis or chromoblostomycosis Adverse effects: renal impairment, BM suppression, liver toxicity, GI symptoms |
|
|
Griseofulvin |
Class: mitotic inhibitor PK: oral MoA: binds tubulin Use: dermatophyte infection Adverse effect: hepatotoxicity, albuminuria, leukopenia, neutropenia, toxic epidermal necrolysis |
|
|
Selenium sulfide |
Use: tinea versicolor and seborrheic dermatitis |
