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18 Cards in this Set
- Front
- Back
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Amphotericin B
Class, Uses and Mechanism |
Polyene
Used for most Fungal infections (except Candida lustaniae and the dermatophytes Binds to Funagl ergosterols and punches holes in the cell membrane |
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Amphotericin B
Toxicity |
1. Infusion
2. Dose-dependent, mainly renal toxicity |
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Azoles
Mechanism |
Inhibition of Cytochrome P-450 which inhibits the conversion of lanosterol to ergsterol, which prevents cell membrane formation
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Imidazole and Triazole
Class |
Azoles
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Flucaonazole
Administration, Excretion, Uses |
Azole
Well-absorbed orally Renal excretion Used for Candida, Crytococcus, Coccidioides Achieves therapeutic CSF levels |
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Itracoazole
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Azole
Variable absorption (fat and acid based) Hepatic metabolism with renal excretion Histo, Blasto, Cocci, Cryto, Aspergillus, Dermatophytes Toxicities: interacts with human CYP-450's, rare cardiac |
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Voriconazole
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Oral, only azole that can be IV
Hepatic and Renal excretion ASPERGILLUS and candida Toxicity: Visual disturbances (reversible) |
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Posaconazole
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Azole
Oral, fat dependent absorption Active against Zygomyces |
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Echinocandins
Our example: Casofungin |
Only IV
Mechanism: inhibits synthesis of glucans necessary for stability of the cell wall Aspergillus and Candida Well-tolerated |
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|
Amphotericin B
Class, Uses and Mechanism |
Polyene
Used for most Fungal infections (except Candida lustaniae and the dermatophytes Binds to Funagl ergosterols and punches holes in the cell membrane |
|
|
Amphotericin B
Toxicity |
1. Infusion
2. Dose-dependent, mainly renal toxicity |
|
|
Azoles
Mechanism |
Inhibition of Cytochrome P-450 which inhibits the conversion of lanosterol to ergsterol, which prevents cell membrane formation
|
|
|
Imidazole and Triazole
Class |
Azoles
|
|
|
Flucaonazole
Administration, Excretion, Uses |
Azole
Well-absorbed orally Renal excretion Used for Candida, Crytococcus, Coccidioides Achieves therapeutic CSF levels |
|
|
Itracoazole
|
Azole
Variable absorption (fat and acid based) Hepatic metabolism with renal excretion Histo, Blasto, Cocci, Cryto, Aspergillus, Dermatophytes Toxicities: interacts with human CYP-450's, rare cardiac |
|
|
Voriconazole
|
Oral, only azole that can be IV
Hepatic and Renal excretion ASPERGILLUS and candida Toxicity: Visual disturbances (reversible) |
|
|
Posaconazole
|
Azole
Oral, fat dependent absorption Active against Zygomyces |
|
|
Echinocandins
Our example: Casofungin |
Only IV
Mechanism: inhibits synthesis of glucans necessary for stability of the cell wall Aspergillus and Candida Well-tolerated |
