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7 Cards in this Set
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- Back
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Amphotericin B
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Mechanism: Macrolide antibiotic, binds ergosterol -> fungicidal, rare resistance, not orally absorbed, 90% bound
Clinical Use: Deep seated mycoses, DOC for fungal CNS infection and rapidly progressing mycoses Side Effects: dose-dependent nephrotoxicity |
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Ketocanazole
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Mechanism: inhibits sterol 14-alpha-demethylase, NOT fungicidal
Clinical Use: broad spectrum, blastomycosis, candidiasis, used only if patient is not gravely ill or immunocompromised Side Effects: GI, cyt P450, elevates Terfenadine to case fatal torades de pointes |
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Fluconazole
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Mechanism: same as Ketaconazole
Clinical Use: DOC for oropharyngeal and esophageal Candidiasis, Cryptococcus(even meningitis in AIDS) fewer side effects than Keto |
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Itraconazole
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Clinical Use: Similar to Ketoconazole, but also lymphocutaneous sporotrichosis and some aspergillosis
Side Effect: prolonged QT interval |
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Voriconazole
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like Fluconazole except works for Aspergillus
Hallucinations up to 30 min |
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Caspofungin
Micafungin |
Mechanism: inhibit synthesis of cell wall glucan, given IV
Clinical Use: Aspergillus and esophageal candidiasis, Candida (altho Fluconazole DOC) |
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Griseofulvin
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Mechanism: binds microtubules -> inhibits mitosis; accumulates in keratinocytes (needs to be taken 1-12 months until skin replaced)
Clinical use: Topical mycoses, Microsporum, Trichophyton, Epidermophyton; NOT used if responds to topical therapy minor side effects |
