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7 Cards in this Set

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Amphotericin B
Mechanism: Macrolide antibiotic, binds ergosterol -> fungicidal, rare resistance, not orally absorbed, 90% bound

Clinical Use: Deep seated mycoses, DOC for fungal CNS infection and rapidly progressing mycoses

Side Effects: dose-dependent nephrotoxicity
Ketocanazole
Mechanism: inhibits sterol 14-alpha-demethylase, NOT fungicidal

Clinical Use: broad spectrum, blastomycosis, candidiasis, used only if patient is not gravely ill or immunocompromised

Side Effects: GI, cyt P450, elevates Terfenadine to case fatal torades de pointes
Fluconazole
Mechanism: same as Ketaconazole

Clinical Use: DOC for oropharyngeal and esophageal Candidiasis, Cryptococcus(even meningitis in AIDS)

fewer side effects than Keto
Itraconazole
Clinical Use: Similar to Ketoconazole, but also lymphocutaneous sporotrichosis and some aspergillosis

Side Effect: prolonged QT interval
Voriconazole
like Fluconazole except works for Aspergillus

Hallucinations up to 30 min
Caspofungin
Micafungin
Mechanism: inhibit synthesis of cell wall glucan, given IV

Clinical Use: Aspergillus and esophageal candidiasis, Candida (altho Fluconazole DOC)
Griseofulvin
Mechanism: binds microtubules -> inhibits mitosis; accumulates in keratinocytes (needs to be taken 1-12 months until skin replaced)

Clinical use: Topical mycoses, Microsporum, Trichophyton, Epidermophyton; NOT used if responds to topical therapy

minor side effects