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16 Cards in this Set
- Front
- Back
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MOA of Amp B and Nystatin
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interact with ergosterol (fungal cholesterol) in fungal membranes to form artificial "pores"
-disrupt membrane permeability |
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Spectrum of Amp B
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DOC for severe infection caused by:
Aspergillus Candida **Cryptococcus** Histoplasma Mucor Sporothrix **Serious systemic fungal infections** |
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What is Amp B synergistic with?
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Flucytosine in candidiasis and cryptococcus
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Side effects of Amp B
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Hypotension (histamine release)
Can be alleviated partly by pretreatment with NSAIDs, antihistamines and adrenal steroids |
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MOA of the Azoles
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Inhibits 14-a-demethylase which converts lanosterol to ergosterol
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Clinical use of Fluconazole
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Cryptococcal meningitis
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Clinical use of itraconazole and voriconazole
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Aspergillosis
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Which azole can penetrate the CNS
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Fluconazole
-can be used in meningeal infections |
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What do azoles do to the P450s
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Inhibit hepatic P450's
-especially ketoconazole |
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Side effects of Azoles
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Decrease synthesis of steroids
-steroids are synthesized by P450s |
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MOA of Flucytosine
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Activated by fungal cytosine deaminase to 5-fluorouracil
5-FU also forms 5-Fd-UMP which inhibits thymidylate synthase --> decrease thymine |
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MOA of Griseofulv
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inhibits microtubule
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Clinical use of Griseofulvin
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active only against dermatophytes
-deposits in newly formed keratin |
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Side effects of Griseofulvin
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Disulfiram like rxn
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MOA of Terbinafine
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Inhibits squalene epoxidase which decreases ergosterol
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Clinical use of Terbinafine
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Active only against dermatophytes
-esp onychomycoses |
