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8 Cards in this Set
- Front
- Back
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Flucytosine
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Inhibits nucleic acid biosynthesis.
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Polyenes
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Binds to ergosterol & forms pore in CM --> ↑ permeability --> leakage
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Griseofulvin
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Conformational changes in tubulin --> ↓ microtubules --> ↓ mitosis
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Terbinafine
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Inhibits squalene epoxidase --> inhibition of ergosterol biosynthesis
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Naftifine
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Inhibits squalene epoxidase --> inhibition of ergosterol biosynthesis
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Morpholines
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Blocks delta 14 reduction and delta 8-8 reduction --> ↓ ergosterol
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Triazoles/Imidazoles
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Inhibits P450 14 α demethylase --> inhibition of ergosterol synthesis
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Echinocandins
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Inhibits 1,3-β-D-glucan synthase --> weak cell wall
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