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17 Cards in this Set
- Front
- Back
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Amphotericin B |
first generation broad-spectrum antifungal, only for serious systemic fungal infections |
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MOA of amphotericin B |
binds ergosterol in cell wall and forms holes in membrane = ions and molecules leak out and lead to cell death |
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AE of amphotericin B |
infusion rxn, nephrotoxicity |
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Nystatin use |
local candidiasis |
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MOA of flucytosine |
converted to 5-FU => metabolized to potent inhibitor of thymidylate synthase, which inhibits fungal DNA and RNA synthesis; used in combination with other drugs |
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Amphotericin B + flucytosine for... |
Cryptococcus neoformans |
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Flucytosine + itraconazol |
dematiaceous molds that cause chromoblastomycosis |
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AE and toxicity of flucytosine |
GI effects, hepatotoxicity, bone marrow suppression (can be lethal) |
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Initial therapy for Aspergillus fumigatus |
voriconazole + an echinocandin |
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Ketoconazole |
first generation azole and has narrow spectrum; inhibits P450s |
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Ketoconazole have basically been replaced by... |
fluconazol and itraconazole, which are more fungal specific |
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First line for invasive candidiasis |
echinocandins and step down to triazole |
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Prophylactic for fungal infections (GVH disease, chemotherapy) |
posaconazole |
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Treatment for cryptococcosis meningitis |
Amphotericin B, followed by additional antifungal agents (fluconazole); given orally for life for some immnocompromised patients |
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Treatment for environmental contamination black mold Exserohilum rostratum caused infections (i.e. meningitis) |
voriconazole first line, with addition of amphotericin B in severe cases |
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Terbinafine |
treatment for onchomycosis and tinea pedis |
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Caspofungin |
well tolderated and improved hepatic and renal safety; work well against Candida; first line and drug of choice ; refractory Aspergillus |
