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8 Cards in this Set
- Front
- Back
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Ketoconazole |
OTC shampoo: dandruff
Oral: systemic fungal infections of lung, bone, skin etc. |
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Pharmacokinetics of Ketoconazole |
Needs an ACIDIC environment (food, antacids, H2 blockers and PPIs impair oral absorption)
Cytochrome p450 (CI with cisapride, lovastatin, simvastatin, midazolam, tiazolam) |
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ketoconazole ADRs |
GI upset Endocrine effects - leading to gynecomastia, decreased libido, impotence, menstrual irregularities
Monitor LFTs weekly!!!! |
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Fluconazole Uses |
IV&oral: Oral and esophageal candidiasis
Oral: vulvovaginal candidiasis
IV&Oral: systemic fungal infection of lung, bone, skin etc |
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Fluconazole ADRs and DIs |
p450 interactions
GI upset, nausea and vomiting, headache
Fatal hepatic toxicity can occur Monitor LFTs periodically |
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Itraconazole Uses |
Onychomycosis Oral and esophageal candidiasis Systemic infections of lung, bone, skin |
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Griseofulvin ADRs |
Rash, itching, headache, fatigue, GI upset, photosensitivity
weak p450 interactions |
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OTC antifungal Creams |
Butenafine Butoconazole CLotrimazole Miconazole Nystatin Terbinafine Terconazole Tioconazole Tolnaftate |
