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11 Cards in this Set
- Front
- Back
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Antifungal Polyenes
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Amphotericin B - Admin by IV, topical, oral, or intrathecal injection; broad spectrum
AE - therapeutic index narrow; nephrotoxic, anemia Nystatin - Admin by oral, topical, and vaginal; candida AE - N/V/D MOA - selectively binds ergosterol --> pore formation |
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Antifungal Azoles
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Fluconazole - oral/IV
Itraconazole - oral/IV Ketoconazole - oral/topical Miconazole - topical/vaginal MOA - inhibits fungal ergosterol biosynthesis Uses - broad spectrum AE - systemic - anorexi, N/V, gynecomastia, dec libido, impotence, mentrual irrgularities, hepatitis, hypokalemia topical - local rxn CI - concomitant Tx w/ rifmycins, caution w/ preg, long QT, torsade de pointes |
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Echinocandins
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Anidulafungin
Caspofungin Micafungin GIVEN IV MOA - noncompetitive inhibitors of fungal enzyme complex --> disrupts fungal cell wall Uses - Aspergillus and Candida AE - GI SE, rash, pruritis, elevated liver enzymes CI - concomitant admin of caspofungin w/ cyclosporine - concomitant admin of micafungin w/ nifedipine, cyclosporine, and sirolimus |
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Others
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Benzoic acid/Salicylic acid combo
Ciclopirox Flucytosine Griseofulvin Terbinafine Tolnaftate Undecylenic acid |
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Flucytosine
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MOA - converted to 5-FU --> 5-FUMP -> inhibits fungal DNA/RNA synthesis
Uses - Aspergillis, Candida, soil fungi AE - myelosuppression, liver dysfxn, toxic enterocolitis |
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Griseofulvin
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Admin oral
MOA - inhibits fungal mitosis Uses - dermatophytes - hair - 1 month - skin/fingernails - 6-9 months - toe nails - 12 months AE - N/V/D/HA, fatigue, blurred vision, vertigo, etc |
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Terbinafine
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Admin oral and topical
MOA - inhibits ergosterol biosynthesis Uses - dermatophytes, Candida, M. furfur AE - N/D, bloating, ab pain, taste disturb, HA CI - concomitant w/ enzyme inducer/inhibitors, drugs metabolized by CYP2D6 |
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Tolnaftate
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Admin topical
MOA - inhibit fungal squalene epoxidase Uses - dermatophytes, M. furfur AE - irritation, allergic contact |
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Ciclopirox
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Admin topical
Uses - cutaneous candidiasis, tinea corporis/cruris/pedis/versicolor, onychomycosis, seborrheic dermatitis |
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Undecylenic Acid
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Admin topical
Used in dermatophytoses, esp tinea pedis |
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Benzoic acid/Salicylic acid
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Admin topical
used in tinea pedis/capitis |
