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9 Cards in this Set
- Front
- Back
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Ketokonazole |
Oral and tropical both |
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Imidazoles and triazole(Spectrum) |
Broad: Dermatophytes, candida, other fungi involved in deep mycosis, Nocardia Leishmania |
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MECHANISM of action |
Inhibit fungal CYP450 and thus impair Ergosterol synthesis ▶️Membrane abnormalities |
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Host toxicity |
Lower ; lower affinity for mammalian CYP450; Inhibits mammalian CYP450 synthesis |
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Resistance |
Fluconazole is resistant to Candida Mutation of gene encoded for fungal 14 demethylase |
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Clotrimazole |
Tropical; for tinea infections Athletes foot ; otomycosis and oral cutaneous vaginal candidiasis Skin infections caused by Corneybacteriym Poor efficacy to Tinea captitis (scalp) and Tinea unguium (nail) No systemic toxicity |
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Econazole |
Similar to clotrimazole Against dermatophytosis; otomycosis; oral thrush Doesn't treat vaginitis No systemic toxicity Local irritations |
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Miconazole |
High efficiacy for Tinea , pityriasis vesicolor, otomycosis Cutaneous and vulvovaginal candidiasis Good penetration so effective in onchomycosis Adverse effects: Irritation; No systemic toxicity |
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Oxiconazole |
Tinea and other dermatophytosis infections; vaginal candidiasis Local irritations |
