Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
8 Cards in this Set
- Front
- Back
|
3 kinds of fungi. |
Yeast Mold Dermatophytes |
|
|
Antifungal ( antimycotics ) Target structures of these medications |
DNA synthesis Mitotic spindle Ergosterol synthesis Membrane function Cell wall synthesis. |
|
|
Inhibitors of nucleic acid synthesis ( DNA synthesis ) Mechanism of action and spectrum. |
Fluocytosine Incorporates itself into the RNA biosynthesis thus disturbing the building of certain essential proteins. Indicates for candida and aspergillus infections.
|
|
|
Inhibitors of mitosis ( mitotic spindle ) |
Griseofulvin Binds tubulin and microtubule-associated protein • Inhibits formation of the mitotic spindle Mostly fungistatic effect. |
|
|
Inhibitors of ergosterol synthesis ( squalene epoxidase ) Mechanism of action |
Naftifine Tolnaftate Inhibits squalene epoxidase, more squalene, which is toxic = fungicidal Indicated for ringworm and athletes foot ( tinea pedis ) |
|
|
Inhibitors of ergosterol synthesis ( 14 alpha demethylase ) |
Coltrimazole Plasma membrane gets de stabilized due to lack of ergosterol. Fungicide. For dermatophytes. |
|
|
Inhibitors of membranes stability ( polyenes ) |
Ampotericin-B Nyastatin |
|
|
Inhibitors of cell wall synthesis ( Echinocandins ) |
Caspofungin Micafungin |
