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29 Cards in this Set
- Front
- Back
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SAE gabapentin
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none
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SAE lamotrigine
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Rash, SJS, TEN, DIC arthritis
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serious skin rxn for lamotrigine incr w *
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more common w concom valproate
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SAE levetiracetam
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None
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SAE oxcarbazepine
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Hyponatremia more common elderly; rash
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SAE tiagabine
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Stupor, spike wave stupor
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SAE topiramate
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nephrolithiasis, open angle glaucoma, hypohidrosis
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SAE zonisamide
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Rash, renal calculi, hypohydrosis
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non ser AE gabapentin
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wt gain, periph edema, behavioral change
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non ser AE lamotrigine
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tic insomnia
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non ser AE levetiracetam
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irritability/behavior chg
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non ser AE oxcarbazepine
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none
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non ser AE tiagabine
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wkness
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non ser AE topiramate
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metab acidosis, wt loss, language dysfxn
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non ser AE zonisamide
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irrit, photosens, wt loss
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newer AED affected by renal dz
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gabapentin, levetiracetam, topiramate
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newer AED affectd by liver dz
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lamotrigine, zonisamide, oxcarbazepine, tiagabine
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oxcarbazepine
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Trileptal
300mg bid; max 1200mg/d |
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zonisamide
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zonegran & generic
initial dose 100 mg daily. titrated q2wks in 100mg increments to 400-600 mg/d |
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tiagabine
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Gabitril
in induced state: 4mg, can be titrated to 56 mg/day in 2-4 doses non-induced: half dose |
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gabapentin
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Neurontin
300-600 mg tid |
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newer AED that do NOT interact w OC
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gabapentin, levetiracetam, tiagabine, zonisamide
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newer AED intx w OC
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OC decr lamotrigine
topiramate decr OC oxcarbazepine decr EE |
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topiramate drug interax
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incr haldol
decr li decr digoxin |
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lamotrigine drug interax
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induces glucuronidation
sl decr valproate |
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topiramate cyp interax
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induces 3A4
inhib 2C19 --> incr DPH |
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oxcarbazepine AED intx
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induces cyp3A4 & glucuronidation; inh 2C19
reduces LMC incr dph or pb |
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Topiramate
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Topamax
200 mg bid; started as 25 mg bid titrated wkly |
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non-epilepsy use for topiramate
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migraine tx
50 mg bid |
