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23 Cards in this Set

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AEDs that block repetitive firing of Na action potentials
Phenytoin
Carbamazepine
Lamotrigine
AEDs that block sustained depolarization
Topiramate
Levetiracetam
Tiagabine
Gabapentin
AED's for generalized seizures
Ethosuximide
Valproic acid
Lamotrigine
Phenytoin
Dilantin (controlled release)

Blocks repeat AP's for focal seizures
Tough to administer
Non-linear kinetics
Metabolized be P450 in liver
Dose changes must be monitored and patient educated to signs of OD
Toxicity of phenytoin
ataxia, nystagmus and lethargy
Idiosyncratic side effects of phenytoin
Rashes, Steven Johnson sndrome and hepatitis
side effects of chronic phenytoin administration
gingivival hyperplasion
coarsening of facial features
hirsuitism

not used for kids
caused coarsening of facial feature and hirsuitism limiting its use in children
phenytoin
pregnancy and phenytoin
can cause any number of birth defects. women of child bearing potential need to be on folate and drug stopped if pregnant
carbamazepine
like phenytoin
needs to be dosed over long period b/c it induces its own metabolism
safe for kids
drug of choic for partial seizures, especially in kids
carbamazepine
unique, dangerous side effects of carbamazepine
leukopenia
aplastic anemia
AED that may cause leukopenia or aplastic anemia
carbamazepine
Its metabolism is inhibited by valproic acid and this interaction may produce rash and Steven's Johnson Syndrome
Lamotrigine
Lamotrigine
like phenytoin with addition action on potassium channels
Used for partial seizures and seizures of Lennox-Gastaut syndrome
Lamotrigine

Tompiramate
Good drug for patients refractory to AED's or with liver dysfunction
Levetiracetam
Absences seizures
Ethosuximide
Ethosuximide
Very safe drug for absence seizures that blocks Ca channels, not Na or GABA

Long half live, metabolized in the liver
Valporic acid
Does it all for men

Side effects for women and a teratogen

Acts on all receptors

Dose dependent thrombocytopenia and elevation of liver enzymes
Causes does dependent elevation of liver enzymes and thrombocytopenia
Valproic acid
Can cause idiosyncratic fulminating hepatitis
Valproic acid
Tx for status epilepticus
Start with Lorazepam immediately
Try fophenytoin
If not, phenobarbital
if not, midazolam, propofol, or pentobarbital