Antiepileptic Drugs/pharm

Front 1

what are the main inhibotory and excitatory neurotransmitters in the brain

Back 1

GABA and glutamate

Front 2

_____of GABA receptor will trigger seizure

Back 2

antagonists

Front 3

______of glutamate receptor will trigger seizure

Back 3

agonists

Front 4

drugs that enhance GABA ergic transmission will

Back 4

inhibit seizures

Front 5

glutamate recpetor antagonists will

Back 5

inhibit seziures

Front 6

what are the Na channel blockers

Back 6

phenytoin
carbamazepine
lamotrigine
zonisamide

Front 7

T type ca channel bloskers

Back 7

ethosuximide
valproate
trimethadione

Front 8

post synaptically enhances gabaergic transmission

Back 8

benzodiazepines
barbiturates
topiramate

Front 9

presynaptically enhances the GABA ergic transmission

Back 9

tiagabine
vigabatrin
gabapentin
pregabalin

Front 10

drugs that reduce glutamatergic transmission post synaptically

Back 10

phenobarbital
topiramate

Front 11

presynaptically reduce glutamatergic transmisson

Back 11

gabapentin
pregabalin

Front 12

drugs that block voltage gated na channels may contribute to the effects of which three drugs

Back 12

phenobarbital
valproate
topiramate

Front 13

inhibition of reuptake of GABA

Back 13

tiagabine

Front 14

inhibition of degradation of GABA

Back 14

vigabatrin: inhibits aminotransferase

Front 15

increases GABA release

Back 15

gabapentin
pregabalin

Front 16

block glutamate receptors

Back 16

phenobarbital
topiramate

Front 17

decrease glutamate release by blocking presynaptically voltage gated ca channels

Back 17

gabapentin
pregabalin

Front 18

for simple and complex partial
and
secondarily generalized tonic clonic seizures
what is the first lien of drug

Back 18

phenobarbital
but now a second line due to AE of sedation, depression, agitation

Front 19

for simple and complex partial
and
secondarily generalized tonic clonic seizures
How do the treartment begin

Back 19

caramazepine and its deravitives like:
oxcarbazepine
or phenytoin

valproate may also be considered.

Front 20

drugs of choice for the tonic clonic seizures

Back 20

phenytoin
carbamazepine
valproate

Front 21

ethosuximide is the drug of choice for

Back 21

absence seizures

Front 22

Acetazolamide is used

Back 22

in the refractory cases of absence seizures

Front 23

if tonic clonic seizures develop in the case of absence seizures then

Back 23

drug of choice is valproate

Front 24

valproic acid is a drug of choice for

Back 24

myoclonic seizures

Front 25

which type of seizure is refractory to all tyoes of medicines

Back 25

atonic seizure

Front 26

what will happen if benzodiazepien is given in case of atonic seizure

Back 26

may improve seizure control in some patients and may worsen the attck in others.

Front 27

which drugs may be beneficial in atonic seizures

Back 27

valproate and lamotrigine

Front 28

what dugs to use in infants and young children

Back 28

corticotropin or corticosteroids

other drugs that can be used are
valproic acid
clinazepam: often tolerence develops.

Front 29

in cases of febrile convulsions

Back 29

rectally diazepam

Front 30

status epilepticus

Back 30

diazepam and lorazepam

Front 31

drug induced seizures in nonepliptic patients can eb controlled with

Back 31

diazepam
lorazepam
phenobarbital

Front 32

approved for breakthu seizures

Back 32

diazepam rectal gel

Front 33

what are the common side effects for carbamazepine
phenobarbital
and phenytoin

Back 33

induce cytochrome P450

Front 34

gingival hyperplasia
coarsening of facial features
hirsutism

Back 34

side effects of phenytoin

Front 35

nystagmus
diplopia
ataxia
and o order elimination

Back 35

phenytoin

Front 36

aplastic anemia
agranulocytosis
thrombocytopenia

Back 36

carbamazepine : and a skin rash

Front 37

what are the non pharmologoloical approaches to seizeures

Back 37

surgery : that part of the brainketogenic diet
vagus nerve stimulation

Front 38

which ones are tetratgeneic

Back 38

phenytoin
carbamazepine
valproate
topiramate
phenobarbital

Front 39

associated with fetal hydantoin syndrome

Back 39

phenytoin

Front 40

associated with spina bifida

Back 40

valproate

Front 41

which ones have the highest risk of major malformations

Back 41

valproate and phenobarbital

Front 42

which drugs are most difficult to discontinue

Back 42

barbiturates and benzodiazepiens

Front 43

what is the most dangerous efeect of overdose of medcations

Back 43

respiratory depression

Front 44

carbamazepine is also used for

Back 44

triegminal neuralgia and bipolar disorder

Front 45

also used for bipolar disorder and migraine prophylaxis

Back 45

valproate

Front 46

used in postherpetic neuralgia

Back 46

gabapentin

Front 47

used in diabetic peripheral neuropathy
postherpetic neuralgia
fibromylgia

Back 47

pregabalin

Front 48

migraine prophylaxis

Back 48

topiramate
valproate

Front 49

inhibits the reuptake of GABA

Back 49

Tiagabine

Front 50

long term therapy assocaited with irreversible visual feild defects in 1/3rd ofthe patients

Back 50

vigabatrin

Front 51

fatal stevens johnson syndrome and toxic epidermal necrolysis have been reported

Back 51

zonisamide
oxcarbazepine

Front 52

acute myopia and glaucoma

Back 52

topiramate

Front 53

stevens johnson syndrome and SLE

Back 53

ethosuximide

Front 54

rapid development of tolerence and paresthesias

Back 54

acetazolamide

Front 55

metabolixed to phenobarbital and phenylethylmalonamide

Back 55

primidone

Front 56

sedation

Back 56

benzodiazepines

Front 57

soulble prodrug of phenytoin for parentral use and is converted to phenytoin in plasma

Back 57

fosphenytoin

Front 58

life threatining rashes and including stevens johnson syndrome

Back 58

lamotrigine

Front 59

drugs that cause stevens johnson syndrome are

Back 59

ethosuximide
lamotrigine
zonisamide
oxcarbazepines
carbamazepine