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13 Cards in this Set
- Front
- Back
Carbamazepine
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Mech: -Na channel block
-blocks catecholamine reuptake - clonidine (alpha2 agonist) blocks anticonvulsant effects use: all but absence seizures; trigeminal neuralgia, bipolar dep, neuropathic pain toxicity: water retention / intoxication (inc. ADH) side fx: less toxic; less sedative notes: stimulates own metabolism, longer take, shorter 1/2 life |
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Phenytoin
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Mech: Na channel block
use: tonic clonic, partial, and psychomotor toxicity: severe skin, bone marrow, liver, gingival, hyperplasia, folic acid deficiency, Ca absorption side fx: notes: Dose dependent elimination; dont give to pregnant women |
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Phenobarbitol
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Mech: enhance GABA effect by keeping GABA receptor open longer
- also blocks Ca channels (not T-type) use: tonic-clonic, simple partial, complex partial toxicity: side fx: convulsions possible w/ withdrawal notes: pH dependent excretion so make urine more alkaline to increase secretion; long 1/2 life - 4 days |
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Valproic Acid
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Mech: Na and Ca (t-type) channel block inhibits GABA breakdown
use: absence, myoclonic, atonic, partial/secondary generalization toxicity: idiosyncratic hepatotoxicity side fx: notes: |
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Ethosuximide
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Mech:blocks t-type Ca channel
use: absence only toxicity: aplastic anemia side fx: LOW B/C DONT USE CYP450 notes: |
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Diazepam (and other BZ's)
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Mech: allosteric modulator of GABA-A causing more frequent Cl- channel opening and hyperpolarization of cell
use:status epilepticus toxicity: side fx:tolerance, highly sedative, ataxia notes: Lorazepam - longer duration for status epil. Clonazepam - oral - for absence Chlorazepate - complex partial |
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Lamotrigine
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Mech: NA channel block
- also anti-folate activity use: partial w/ secondary generalization toxicity: side fx: notes: Group I |
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Felbamate
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Mech: Na channel block
NMDA block enhances GABA use: partial toxicity: aplastic anemia side fx: notes: Group I - back on market now but must monitor carefully |
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Topiramate
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Mech: Na channel block
inhibits AMPA enhances GABA use: intractable partial seizures and 2ndary agent for partial seizures toxicity: side fx: weight loss notes: Group I -weak carbonic anhydrase inhibitor |
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Vigabatrin
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Mech: inhibits GABA-T
use: partial seizures toxicity: sedation, agitation, weight gain, psychosis side fx: notes: Group II |
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Tiagabine
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Mech: inhibits GABA-T
use: adjunctive partial seizures toxicity: abnormal thinking - mental lethargy or difficulty concentrating side fx: notes: Group II |
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Gabapentin
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Mech: controversial:
-binds to GABA B heterodimer linked to K and N-type VGCC Ca channel: overexpressed in nerve injury; N, L, P/Q-type VGCC -may interact at presynaptic NMDARs ( /) -non-vesicular GABA use: partial toxicity: side fx: notes: Group II NOT METABOLIZED by CYP450, NO INTERACTIONS |
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Levetiracetam
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mech: selective blockade of n-type Ca channels
- reduction of voltage operated K current - does not modulate neuronal Na and T-type Ca2+ currents Use: refractory partial seizures notes: Group II NOT METABOLIZED BY CYP450, little side fx |