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17 Cards in this Set
- Front
- Back
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Four ways to stimulate nausea and vomitting
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stretch afferents in stomach
stimulus of the Area Postrema Vestibular afferents Higher cortical centers |
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Exception to the rule that drugs for motion sickness don't work for drug induced nausea
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promethazine
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Promethazine is unique because
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it is effective against motion sicknes and drug-induced nausea
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Drugs that work for motion sickness also work for...?
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nausea induced by vertigo
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Drugs for motion sickness
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muscarinic antagonists of histamine anatgonists
scopolamine dimenhydrinate hydroxyzine Must use 1 hours before (4 hours if transdermal) |
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Motion sickness drugs side effects
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sedation and antimuscarinic effects
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Ondansetron
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5HT-3 antagonist
1st line anti N/V from operation, opiates or chemo |
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1st line antiemtic that can be used alone or combined for different uses
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Ondansetron
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Its prokinetic effects is atropine sensitive
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Metoclopromide
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Metoclopromide
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Dopamine antag, prokinetic
May produce akathisia, dystonic reactions Sensitive to atropine |
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Safe alternative to metoclopromide
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Domperidone
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Domperidone
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Alternative to metoclopromide because it doesn' cross the BBB
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Third line rescue therapy for chemp N/V
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phenothiazines
Chlorpromazine Prochlorperazine Have high incidence of extrapyramidal side effects |
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Chlorpromazine
Procholorperazine |
Third line anti cancers due to extra pyramidal side effects
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Greatly enance effectiveness of other antiemetics
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Dexamethasone
Used with Ondansetron for actue emesis from drugs |
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Dexamthasone
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Enhances effectiveness of other cancer drugs
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Lorazepam
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Pretreatment to reduce stress and anticipatory emesis
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