Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
25 Cards in this Set
- Front
- Back
|
Fluoxetine
|
Prozac
|
|
|
Paroxetine
|
Paxil
|
|
|
Sertraline
|
Zoloft
|
|
|
Fluvoxamine
|
Luvox
|
|
|
Citalopram
|
Celexa
|
|
|
Escitalopram
|
Lexapro
|
|
|
SSRIs have more SE than TCAs (True or False)
|
False, they have less side effects than TCAs
|
|
|
Should SSRIs be taken in the AM or PM?
|
AM because they increase alertness
|
|
|
What are some SE of SSRIs?
|
Anxiety/panic attacks
Insomnia Agitation/jitteriness Sexual dysfunction Apathy/anhedonia DA release inhibition Weight Loss Nausea, GI distress, Increased bowel motility |
|
|
SSRIs are metabolized by _____
|
CYP450
|
|
|
SSRIs are further classified by their 1/2 life. The short 1/2 life SSRIs are:
|
Paroxetine (Paxil)
Fluvoxamine (Luvox) |
|
|
The moderate 1/2 life SSRIs are:
|
Sertraline (Zoloft)
Citalopram (Celexa) Escitalopram (Lexapro) |
|
|
The long 1/2 life SSRI is:
|
Fluoxetine (Prozac)
Norfluoxetine = active metabolite |
|
|
What is discontinuation syndrome?
|
Results when an antidepressant is suddenly discontinued. Flu like symptoms occur along with anxiety, tremor, GI distress, mood and appetite changes. Worse with the short acting drugs (Paroxetine, Fluvoxamine, TCAs, Venlafaxine)
|
|
|
The advantages of Fluoxetine (Prozac) include:
|
Free of Anti-SLUDGE
Free of Orthostatic Hypotension Free of Weight Gain |
|
|
How does Fluoxetine (Prozac) effect CYP metabolism?
|
Fluoxetine is a CYP inhibitor (2D6, 3A4). Therefore, it should not be used with TCAs, Antipsychotics, Antiarrhythmics, and Beta-adrenergic antagonists.
|
|
|
Adverse Effects of Fluoxetine (Prozac)
|
Nausea, Diarrhea, Abdominal Pain
Anxiety; Akathisia, Agitation Insomnia, fatigue Minimal Cardiovascular Side Effects Sexual Dysfunction |
|
|
When does Serotonin Syndrome occur?
|
When several serotonergic drugs are combined (TCAs, SSRIs, SNRIs, and MAOIs)
|
|
|
How many weeks should a patient wait before using another AD after using Prozac?
|
5 weeks to prevent Serotonin Syndrome
Prozac is a long acting AD |
|
|
What are the symptoms of Serotonin Syndrome?
|
Agitation
Restlessness Confusion Insomnia HTN crisis GI symptoms Diaphoresis (Sweating profusely) Rigidity Hyperthermia Seizures leading to Coma |
|
|
Which 2 SSRIs are the most sedating?
|
Paroxetine (Paxil)- think PJs!
Fluvoxamine (Luvox)- think when you have the flu, you want to sleep! |
|
|
Which SSRI has mild anti-SLUDGE effects?
|
Paroxetine (Paxil)
|
|
|
Which 2 SSRIs can cause agitation, anxiety, and insomnia?
|
Fluoxetine (Prozac)
Sertraline (Zoloft) |
|
|
What 2 SSRIs can cause Diarrhea?
|
Sertraline (Zoloft)
Fluvoxamine (Luvox) |
|
|
Paroxetine (Paxil) has anti-SLUDGE effects including:
|
dry eyes, blurred vision
xerostoma tachycardia constipation urinary retention change of mental status memory impairment |
