Antidepressants-Pharm

Front 1

TRANYLCYPROMINE

Give Category of Drug
M.O.A.
Uses

Back 1

MAOI=monoamine oxidase inhibitor-- Reversible one

Monoamine oxidase = a presynatptic enzyme responsible for metabolizing NE and Serotonin(MOA-A) and Dopamine (MOA-B)

By inhibiting Monoamine oxidase these drugs increase the levels of serotonin, NE, and dopamine in the presynaptic neuron.

Used to treat atypical depression, specefic phobias, and panic disorders.

Front 2

PHENELZINE

Class
M.O.A.
Use
S.E.

Back 2

MOAI- nonreversible

acts to inhibit the presynaptic enzyme monoamine oxidase, and by doing so it increases the the levels of NE, Serotonin, and Dopamine in the presynaptic neuron

Clinical Uses: atypical depression, specefic phobias, and panic disorder

S.E. = Sedation, Hypotension, blurred vision, and weight gain

Front 3

ISOCARBOXAZID

Class
M.O.A.
Uses
S.E.

Back 3

MOAI- nonreversible

acts to inhibit the presynaptic enzyme monoamine oxidase, and by doing so it increases the the levels of NE, Serotonin, and Dopamine in the presynaptic neuron

Clinical Uses: atypical depression, specefic phobias, and panic disorder

S.E. = Sedation, Hypotension, blurred vision, and weight gain

Front 4

What are some potential toxicities to be aware of with MOAIs?

Back 4

1.Hypertensive crisis with the ingestion of Tyramine-"wine and cheese Reaction", HTN-crisis also cased by Beta agonists

2.Serotonin Syndrome- autonomic instability, hyperthermia, myoclonus, confusion, delerium, and coma---this is why SSRI's and Meperidine, OTC decongestants, most TCA's, and diet pills(ephedrine) are contraindicated with MAOIs

Front 5

IMIPRAMINE

Class
Uses
M.O.A.
S.E.

Back 5

TCA= Tricyclic Antidepressant

Uses: Major Depression and Enuresis = bedwetting

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 6

AMITRYPTILINE

Class
Uses
M.O.A.
S.E.

Back 6

TCA= Tricyclic Antidepressant

Uses: Major Depression

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 7

DESIPRAMINE

Class
Uses
M.O.A.
S.E.

Back 7

TCA= Tricyclic Antidepressant

Uses: Major Depression

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 8

NORTRIPTYLINE

Class
Uses
M.O.A.
S.E.

Back 8

TCA= Tricyclic Antidepressant

Uses: Major Depression

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 9

CLOMIPRAMINE

Class
Uses
M.O.A.
S.E.

Back 9

TCA= Tricyclic Antidepressant

Uses: Major Depression and OCD (obsessive compulsive disorder)-note this is the only TCA used for this

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 10

DOXEPIN

Class
Uses
M.O.A.
S.E.

Back 10

TCA= Tricyclic Antidepressant

Uses: Major Depression

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 11

AMOXAPINE

Class
Uses
M.O.A
S.E.

Back 11

TCA= Tricyclic Antidepressant

Uses: Major Depression

M.O.A. = TCA's block the reuptake of NE and Serotonin from the synaptic cleft and thereby potentiate the effects of NE and serotonin on the postsynaptic receptors

S.E.=
1.Anticholinergic- due to muscarininc blockade= dry mouth, excess perspiration, constipation, blurred vision, mydriasis, and urinary retention
2.alpha-1-adrenergic blockade= orthostasis and cardiac arrhythmias, long QT, and depressed ST
3.Histamine Blockade= Sedation, weight gain, and sexual S.E.
4.Cardiac Toxicity= palpitations, tacchycardia
5.Sexual S.E. = loss of libido, imparied erection,ejaculation, and anorgasmia.= decreases compliance
6.TCA's also can lower seizure thereshold.

Front 12

The use of TCA's with ____________ group of drugs is contraindicated due to risk of seizures.

Back 12

MAOIs

Front 13

TRAZODONE

Class
M.O.A.
S.E.

Back 13

SARI = serotonin 2 antatgonist and reuptake inhibitor--- it blocks 5HT2 and 5HT1 receptors and is a weak inhibitor of serotonin reuptake

Main use = Insomnia b/c too high of doses are required to achieve antidepressant effects

S.E. = sedation, orthostasis, and priapism

Front 14

NEFAZADONE

Class
M.O.A.

Back 14

SARI = serotonin 2 antagonist and weak serotonin reuptake inhibitor.---similar to Trazodone except less sedation and no priapism. It also blocks muscarinic Ach receptors.

Used as an antidepressant

Front 15

MIRTAZAPINE

Class
M.O.A.
S.E.

Back 15

NaSSA = noradrenergic and specefic serotonin antidepressant

M.O.A. = Alpha-2 antagonist which alpha 2 is presyanptic and usually it inhibits the release of NT, but since we are inhibiting it the alpha 2 blockade causes an increase in the release of NT (specefically NE and Serotonin).
It is also a potent 5HT2 & 5HT3 receptor antagonist

S.E. = sedation, constipation, and wight gain

Front 16

VENLAFAXINE

Class
M.O.A.
S.E.

Back 16

Class= SNRI= serotonin and NE reuptake inhibitor

M.O.A = potent 5HT and NE reuptake inhibition

S.E.= nausea, vomitting, dizziness, sedation, increased BP, and stimulant effects