Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
56 Cards in this Set
- Front
- Back
|
What is Clomipranine used for?
|
Only OCD
|
|
|
Monoamine oxidase inhibitors
|
Phenelzine
Tranylcypromine |
|
|
what are the 3 diff types of antidep?
|
Tricylcics
Monoamine Oxidase inhibitor Selective Serotonin reuptake inhibitors |
|
|
Tricyclines blocking acetyl and histamine is that theraputic?
|
not therauptic effect
|
|
|
Postural hypotension
|
fainting upon standing up
|
|
|
Tricyclics side effects?
|
all drugs haev same side effects drowsiness,blurred vision,
|
|
|
Uses of Tricyclics
|
Very effective in chronic neuropathic pain
|
|
|
What is Imipranine used for?
(antidepressant) |
Used for ADHD
|
|
|
What is the bad thing about antidepressants?
|
One of the ways depressed patients attempt suicid is ODing on antidep pill- looks like- cardiac arythmia, cardiac depression, excitiment, delirium, convulsions, respiratory depression, coma
|
|
|
Are tricyclics still used for depression?
|
no they are too dangerous
|
|
|
What does monoamine oxidase inhibit the break down of?
|
Inhibits break down of dopamin, norepinephrine and seratonin
|
|
|
Monoamine Oxidase Inhibitors irreversibly do what?
|
Irreversibly prevent breakdown of monamines inlcuding: dopamin, norepinephrine and seratonin
|
|
|
What does the moi do to the body?
|
It will cause hypothermia and need for hospitalization takes two weeks to get maois back
|
|
|
If taking monoamine oxidase inhibitors what foods should u stay away from?
|
cant take foods with tyromine, cheese, wine, chocolate- because it builds up more norepinephrine
|
|
|
Selective serotonin reuptake inhibitors (SSRI's) (antidepressant drugs)
|
Given alot now for depression
|
|
|
OD of SSRI, what happens?
|
Serotonin syndrome- invloves- confusion, agitation, fever, hypertension, increased reflexes, halucinations
no need for long hospitalization |
|
|
Side effects of MAOIs
|
weight gain, sedation, orthostatichypotension= posturohypotension
|
|
|
Side effects of SSRIs
|
insomnia or sedation
nausea agitation headaches sexual dysfunction |
|
|
SSRI's list
|
celexa, lexapro,prozac,luvox,paxil, zoloft
|
|
|
SSRI withdrawal syndroms- abrupt stop
|
flu like symtpoms, nausea,vomitting, diarreah, dizziness, parasthesia- numbness and tingling of extremities, vivid dreams, anxiety and crying, depression, memory probs, confusion,
|
|
|
Atypical antidepressants
|
newer drugs made after ssris
|
|
|
Mirtazapine (remirone) Atypical
|
alpha 2 antagonist increase levels of norepinephrine
|
|
|
DRI
|
Dopamine Reuptake Inhibitor
|
|
|
NRI
|
Norepinephrine reuptake inhibitor
|
|
|
SRI
|
Non selective serotonin reuptake inhibitor
|
|
|
SNRI
|
Seratonin norepinephrine reuptake inhibitor
|
|
|
plavix cause and ssris
|
cause pulmonary hypertension and heart defects in newborns
Pregnancy category D -plavix |
|
|
Is prozac dangerous?
|
yes it is black boxed
|
|
|
Anxiety Agents
|
Benzodiazepine
Nonbenzodiazepine |
|
|
mechanism of action of benzodiasepine
|
increases gaba by working in the brain at a gaba complex- bind to benzodiazepine receptors
|
|
|
Do we have endogenous benzodiasepines?
|
Yes we do, foods also have benzodiasepines
|
|
|
Whats bad about benzodiasepines?
|
Cause addiction, physical dependence
|
|
|
What doe benzodiasepines do outside of antianxiety?
|
they are sedative, relax muscles, tension headaches, used in surgurey for so you dont remember surgery
|
|
|
What kind of amnesia do Benzodiasepines cause?
|
cause anterograde amnesia
|
|
|
lithium and benzodiazepines side effect
|
look like they are drunk
|
|
|
what class is valium?
|
It is schedule IV and highly addictive
|
|
|
what is bad about Ativan?
|
Worst to get off of, withdrawal is extremely bad
|
|
|
all benzodiazepines are which schedule?
|
Schedule Iv
|
|
|
Are benzo's ok for pregnancy?
|
No they cause floppy infant syndrome- hypotonia, hypothermia, decreased respiration, hyperexcitable, delayed motor coordination
|
|
|
what are effects of Taking benzo's for long term
|
starts off with a lot of gaba and inhibiting glutamate, long term
same release of gaba but glutamate increases to compensate for benzodiazepines- symptoms will be opposite benzos |
|
|
Is it good to get off benzo's?
|
no, brain will get worse, more glutamate will form each time u go back on- glutamate is toxic to brain
|
|
|
Is glutamate good for the brain?
|
No it is toxic for the brain
|
|
|
Nonbenzo's
|
almost all have serotonin reuptake inhibition, do not cause addiction
|
|
|
Benzo names to know
|
Xanax Valium and Ativan
|
|
|
fear
|
if enough serotonin in amygdala it will decrease fear
|
|
|
Non benzos cause
|
dry mouth, dizziness
|
|
|
Hydroxazine is not an antipressant but a?
|
antihistamine
|
|
|
Desyrel
|
Causes retrograde ejaculation,
priopism- also ssri's cause this- prolonged erection. |
|
|
desyrel also causes
|
altered libido, retrograde ejactulation- semen backs up into urine
|
|
|
What are Sedative Hypnotics
|
sleeping pills- hardest drug to get off of. benzodiazepines, and nonbenzodiazepines
|
|
|
Side effects of sedative hypnotics
|
benzos-daytime sedation- depends on half life of drug, nonbenzos- all drugs except for roserem are gaba agonists
|
|
|
Non benzo sedative hypnotics addictive like benzos?
|
yes except for roserem
|
|
|
Side effects of lunesta (nonbenzos)
|
memory probs, tolerance, withdrawal, dependence,
|
|
|
Is lunesta easy or hard to get off?
|
very hard
|
|
|
Behavior changes on lunesta
|
more aggressive, hallucination, assertive, suicidal thoughts,
|
|
|
Ambien (sedative hypnotic) side effects
|
sleep driving, eating, having sex, sleep walking, making and eating food,
|
