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6 Cards in this Set

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Phenelzine
Tranylcypromine
nonselective MAO inhibitors
AD require inhibition of MAO A

Clinical use: 2-3rd line antidepressant

Side Effects: ine and Chees syndrome w/ ephedrine and food w/ tyramine; serotonin syndrome w/ SSRI or SNRI
Fluoxetine(Prozac)
Sertraline(Zoloft)
Fluvoxamine
Paroxetine(Paxil)
SSRIs: 5-HT uptake inhibitors

Clinical Use: Major Depression, Anxiety, Panic Disorder, OCD (less effective than TCA in severe depression)

Side Effects: nausea, insomnia, sexual dysfunction, rash, leukocytosis, do NOT combine with MAOIs
Amitriptyline
Nortriptyline
Imipramine
Desipramine
Clomipramine
TCAS: NE/5-HT reuptake inhibitor, also antimuscarinic, antiH and antialpha-1

Clinical use: Unipolar depression, panic disorder

Side Effects: sedation, hypotension, cardiac toxicity, cholinergic blockade, seizure, overdose with 10-20x daily dose
Reboxetine
selective NE reuptake inhibitor
Depression
Venlafaxine
selective 5-HT and NE reuptake inhibitor
antidepressant
Bupropion
releases DA, stimulant
Antidepressant assoc w motor retardation
(low dose) lowers discomfort of nicotine withdrawal