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21 Cards in this Set
- Front
- Back
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What are the SSRI's?
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Fluoxetine, paroxetine, setraline, citolapram.
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Mech of action for SSRI?
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serotonic specific reuptake inhibitor
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Clinical use for SSRI?
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depression, general anxiety disorder, panic disorder, OCD, bulemia, phobias, PTSD
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Toxicity for SSRI?
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GI distress, sexual dynfunction,
SEROTONIN SYNDROME - hyperthermia, confusin, myoclonus, CV colapse, flushing, diarrhea, seizures. Give cyproheptadine for SS. |
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SNRI, what are they?
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venlafaxine, duloxetine
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Mech of actoin for SNRI?
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Inhibit serotonin and NE reuptake.
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Clinical use for SNRI?
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Depression. Venlafaxine also used in GAD and panic disorder.
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Toxicity for SNRI?
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Increase in BP, stimulant effects, sedation, nausea
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What are the TCA's?
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-tryptiline, -ipramine, doxepin, amoxapine
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Mech of action for TCA?
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Bloc reuptake of serotonin and NE
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Clinical use for TCA?
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Major depression, bedwetting (imipramine), OCD (clomuiprimine), fibromyalgia.
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Toxicity for TCA?
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Sedation, a1-blocking effects leading to postural hypotension, atropine-like effects (tachy, urinary retention, dry mouth).
Tri-C's: Convulsions, Coma, Cardiotox. also respiratory depression, hyperpyrexia. Use NaHCO3 for CV tox. |
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MAOI's, what are they?
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Tranylcypromine, phenelzine, isocarboxazid, selegiline (MAO-B inhibitor)
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Mech of action for MAOI?
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non-selective MAO inhibition increases levels of amine neurotransmitters (NE, serootonin, dopamine).
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Clinical use for MAOI's?
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Atypical depression, anxiety, hypocondriasis.
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Toxicity for MAOI's?
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Hypertensive crissis (esp when ingesting tyramine (wine, cheese)). CNS stimulation, Don't take with SSRI, TCA, St. John's Wort, meperidine, and dextromethorphan or else you could get SS.
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What are the atypical anti depressants?
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Bupropion, Mirtazipine, Maprotiline, Tazodone
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Toxicity for Bupropion, and other use?
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Also used for smoking cessation
stimulant effects (tachy, insomnia), HA, seizure. No sexual side effects (SSRI's have this) |
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Mech of action for Mirtazapine?
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A2-antagonist (increases release of serotonin and NE) and potent 5HT2 and 3 antagonist.
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Toxicity for Mirtazapine?
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sedation, increased appetite, weight gain, dry mouth.
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Trazodone Mech of action and toxicity?
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inhibits serotonin reuptake. IUsed for insomnia, and antidepressant at high levels.
Toxicity is sedation, nausea, priaprism, postural hypotension. |
