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18 Cards in this Set
- Front
- Back
- 3rd side (hint)
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amitriptyline
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TCA
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elavil
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clomipramine
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TCA
**labeled use for OCD |
anafranil
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desipramine
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TCA
*most potent TCA **high affinity for NET (not SERT) ***down-regulates alpha-1 & causes desensitization of alpha-2 |
Norpramin
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doxepin
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TCA
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Sinequan
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imipramine
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TCA
*First clinically used **Also indicated for bedwetting |
Tofranil
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protriptyline
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TCA
**has unsaturated bridge in the middle ring (at the top) |
Vivactil
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Trimipramine
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TCA
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Surmontil
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amoxapine
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tetracyclic/unicyclic (which is why it looks totally different--> has the O and N in the ring)
*used in delusional depression (why?) |
Ascendin
metabolite of loxapine (a benzazepine anti-psychotic) |
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Maprotiline
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tetracyclic/unicyclic
Why is it special? |
Has an ethylene bridge in its central ring
*Has the highest affinity and selectivity for NET **associated with dose-dependent seizures compared to other TCAs |
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isocarboxazid
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MAOI
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Marplan
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phenelzine
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MAOI (nonselective)
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Nardil
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selegiline
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MAOI (selective for MAO-B at low doses... at high doses= nonselective)
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tranylcypromine
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MAOI
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Parnate
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bupropion
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tetracyclic/unicyclic
**smoking cessation |
Wellbutrin
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mirtazapine
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tetracyclic/unicyclic
*has a clinical use for sedation |
Remeron
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nefazodone
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5-HT2 antagonist
Common SEs= sedative & GI Sexual SEs are rare |
* black box warning for hepatotoxicity
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trazodone
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5-HT2 antagonist
Common SEs= sedative & GI Sexual SEs are rare |
Desyrel
*more sedative effect (unlabeled use as a hypnotic) **rarely associated with priapism (longer than 8 hrs) |
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Explain the MOA of trazodone & nefazodone
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5-HT2 antagonists
5-HT1a receptor is linked with depression & 5-HT2a/c are linked with sexual dysfunction, insomnia, anxiety By blocking 5-HT2a, they are pushing more serotonin onto the 5-HT1a receptor--> increasing the antidepressant effect (also, this is the reason for the decreased sexual SEs seen with this medication, priapism, sedation) |
At low doses, trazodone acts as a sedative
At high doses it acts as an antidepressant it also blocks the reuptake of 5HT (SERT) |
