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7 Cards in this Set
- Front
- Back
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SSRIs
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Fluoxetine, paroxetine, sertraline, fluvoxamine, citalopram
Selective serotonin reuptake inhibitors (SSRIs) - 1st line RNAM of 5HT transporter (reuptake) safe and easier than TCAs (and venlaxafine) side effects - git, cns, sexual, other may have incr suicidal ideation in some patients at start of Rx "serotonin syndrome" - dont combine with MAOI or RIMAs |
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NaSSAs
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Mirtazapine
Noradrenaline-serotonin specific antidepressants antagonists presynaptic inhibitory NA & 5HT (lots of receptors) especially for patients with insomnia (and ssri sexual dysfunction) |
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RIMAs
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Moclobemide
Reversible inhibitors of monoamine oxidase A especially for fatigued patients (and ssri sexual dysfunction) no tyramine reaction (reversible) |
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SNRIs
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Venlaxafine
Serotonin & noradrenaline reuptake inhibitors 2nd line RNAM of NA & 5HT reuptake transporter (compared to TCAs: lacks M, a1 and H1 receptor affinity - no impaired cardiac conduction) weak CYP2D6 |
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TCAs
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desipramine, nortriptyline, amitriptyline, imipramine
Tricyclic Antidepressants - 3rd line RNAM of Na & 5HT reuptake transporters Side-effects Overdose Toxic Sedating |
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NRIs
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Reboxetine
Noradrenaline reuptake inhibitors RNAM of NA reuptake transporter |
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MAOIs
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Phenelzine
Tranylcypromine IRREVERSIBLE inhibiton of MAOa and MAOb "tyramine reaction" |
