Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
6 Cards in this Set
- Front
- Back
|
Mechanism of Reserpine
|
Partially depelets CNS biogenic amines (NE, 5HT) and causes depression.
Due to functional decrease in NE and 5HT transmission, or its long term consequences. |
|
|
Disadvantages of Reserpine
|
Depression
|
|
|
Mechanism of tricyclic antidepressants
|
Cardiovascular effects are anticholinergic action and direct cardiotoxicity leading to tachycardia and dysrthymias, and postural hypotension. Parkinson's.
|
|
|
Mechanism of SSRI's Fluxoxetine (Prozac)
|
Many are in pairs with a drug/active metabolite.
It only affects 5HT. NO efefct on NE reuptake. Higher TI. P450 inhibitors. |
|
|
Risperidone (Risperdal)/Olanzapine (Zyprexa)
|
Atypcial 2nd generation antipsychotic.
Block more of the 5HT than D2 receptor. Lower incidence of extrapyramidal effects and have sedation/autonomic effects still present. Better at reducing schizophrenia |
|
|
Side effects of antidepressants
|
tricyclic effects which are sedation, muscle weakness, OH, and St. John's Wort.
|
