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23 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Imipramine
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Tricyclic
SidEf- sedation, anticholinergic effect (dry mouth, constipation, blurred vision, urinary retention etc.) OvDose- dysrhytmias (when combined with CNS depressor) t1\2- 4-18 h |
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Desipramine
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Tricyclic
NA selective. SidEf- sedation, anticholinergic effect. OvrDos- dysrhytmia (when combined with CNS depressor) t1\2- 12-24h |
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Amitriptyline
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Tricyclic
SidEf- sedation, anticholinergic effect. OveDos- dysrhytmias (when combine with CNS depressor). t1\2- 12-24h. widely used, also for neuropathic pain. |
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Nortriptyline
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Tricyclic
NA selective (slight) SidEf- sedation, anticholinergic effect. OvrDos- dysrhytmia (when combined with CNS depressor) t1\2- 24-96h. less sedative. |
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Clomipramine
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Tricyclic
Sidef- sedation, anticholinergic effect. OvrDos- dysryhtmia (when combine with CNS depressor). t1\2- 18-24h. also used for anxiety disorders |
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Tricyclic
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a group of antidepressant that inhibit Noradrenalin (NA) \ serotonin (5HT) reuptake .type of drugs-
Imipramine Desipramine Amitriptyline Nortriptyline Clomipramine |
type of drugs-
Imipramine Desipramine Amitriptyline Nortriptyline Clomipramine |
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Fluoxetine
AKA Prozac |
SSRI
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- low risk, most not be used combined with MAOI. t1\2- 24-96h |
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Fluvoxamine
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SSRI
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- low risk, most not be used combined with MAOI. t1\2- 18-24h |
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Paroxetine
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SSRI
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- low risk, most not be used combined with MAOI. t1\2- 18-24. less nausea then other SSRI. |
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Citalopram
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SSRI
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- low risk, most not be used combined with MAOI. t1\2- 24-36. Withdrawal reaction. |
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Sertraline
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SSRI
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- low risk, most not be used combined with MAOI. t1\2- 24-36h |
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SSRI
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Selective serotonin (5HT) reuptake inhibitors class of antidepressant drugs, include:
Fluoxetine Fluvoxamine Paroxetine Citalopram Sertraline |
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Phenelzine
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MAOI
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- low risk, most not be used combined with MAOI. t1\2- 24-36. Withdrawal reaction. |
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Tranylcypromine
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MAOI
SidEf- Cheese reaction to tyramine (foods), anticholinergic effect, HypoTens, insomnia, weight gain, liver damage (rare). OvrDos- interaction with Tricyclic, opioids, sympathomimetics), risk of sever HT due to cheese reaction. t1\2- 1-2 h (irreversible binding) |
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Isocarboxazid
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MAOI
SidEf- Chees reaction to tyramine (foods), anticholinergic effect, HypoTens, insomnia, weight gain, liver damage (rare). OvrDos- interaction with Tricyclic, opioids, sympathomimetics), risk of sever HT due to cheese reaction. t1\2- 39h |
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Moclobemide
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MAOI
MAO-A selective. SidEf- nausea, insomnia, agitation. OvrDos- less sever interaction the other MAOI, no cheese reaction (tyramine). t1\2- 1-2h. safer then other MAOIs. |
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MAOIs
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Monoamine oxidase (A or B) inhibitors, inhibit formation of monoamines (neurotransmitters).
types: Phenelzine Tranylcypromine Isocarboxazid Moclobemide |
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Maprotiline
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selective NA uptake inhibitor
SidEf- sedation, anticholinergic effect. OvrDos- dysrhytmias (when combined with CNS depressor). t1\2- 40h no significant advantages over tricyclic. |
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Reboxetine
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selective NA uptake inhibitor
SidEf- dizziness, insomnia, anticholinergic effect. OvrDos- safe, low risk of dysrhytmia. t1\2- 12h safer & fewer SidEf then tricyclic. |
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Venlafaxine
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weak non selective NA\5HT uptake inhibitor. also blocks receptors.
SidEf- nausea, diarrhea, agitation, insomnia, anorgasmia, inhibit metabolism of other drugs. OvrDos- safe. withdrawal effects common. t1\2- 5h faster working, better with resistant patients. |
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Bupropion
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weak Dopamine uptake inhibitor
SidEf- dizziness, anxiety, seizures. OvrDos- safe. t1\2- 12h used mainly in depression associated with anxiety. |
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Trazodone
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weak serotonin (5HT) uptake inhibitor, also blocks receptors.
SidEf- sedation, HypoTens, dysrhytmia. OvrDos- safe. t1\2- 6-12h similar- Nafazodone, Mianserin |
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Mirtazapine
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block alfa2, 5HT2/3 receptors
SidEf- dry mouth, sedation, weight gain. OvrDos- no serous interaction. t1\2- 20-40h. faster onset then other. |
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