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17 Cards in this Set

  • Front
  • Back
Phenobarbitol
Increases GABA and decreases Ca
Induces cytP450
Primarily used for GTC seizures
Can causes cognitive deficits in children
Phenytoin
Fosphenytoin (IV)
Decreases Na permeability
Gingival Hyperplasia
Dose related nystagmus and ataxia
Fetal Anticonvulsant Syndrome
Nonlinear metabolism- hard to dose
Contraindicated in Absence Seizures
Induces Cyt P450 and increases metabolism of APs
Carbamazepine
Decreases Na Permeability
GI, visual and hematologic side effects (leukopenia-CBC regularly)
Autoinduces its metabolism
Also for Trigem Neuralgia and Bipolar
Sodium Valproate
Divalproex
Increases GABA and inhibits ion channels
Weight Gain, Alopecia, and Hepatotoxicity
Metabolic effects
Fetal Anticonvulsant Syndrome
Ethosuximide
First line for Absence Seizures
Blocks T Type Ca channels
Also inhibits NADH Aldehyde Reductase
Diazepam
Lorazepam
Increase GABA
For Status and Alcohol WD
Not effective for long
Clonazepam
Increases GABA
For Lennox Gastaut, Myoclonic and Akinetic seizures
Felbamate
Decrease Glutamate via NMDA
Adjuct therapy: Lennox Gastaut and Partial seizures
Life threatening SEs: Aplastic anemia and hepatotoxicity
Lamotrigine
Inhibits Na channels
Approved for use in refractory patients with Partial seizures
Microbilliform Rash can progress to Stevens Johnson Syndrome (Don't combine with Na Valproate)
Gabapentin
Adjunct for partial seizures
Increases GABA
Eliminated by kidneys so few drug reactions
Also for peripheral neuropathy
Pregabalin
Adjunct for partial seizures
More potent alternative to Gabapentin
Binds Ca channel to decrease influx
Topiramate
Approved monotherapy for new patients with Partial seizures
Increases GABA and decreases Glu via AMPA
Weak inhibitor of carbonic anhydrase: Kidney Stones
Tiagabine
Adjunct for partial seizures
Increases GABA
May increase non-epileptic seizures
Spike Wave Stupor
Levetiracetam
Adjunct for partial seizures
Binds synaptic vesicular protein and modifies release of GABA and Glu
Zonisamide
Adjunct for partial seizures
Inhibits Na channels
Kidney Stones
Lacosamide
Adjunct for partial seizures
Inhibits Na channels
PR prolongation
Rufinamide
Adjunct for partial seizures and Lennox Gastaut
Inhibits Na channels
QT interval shortening