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6 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Phenobarbitol and other barbituates
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MOA: allosteric binding to GABA(A) receptor, potentiating activity
Treat: partial not used much anymore bc of SE |
GABA
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Benzodiazepines
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MOA: allosteric potentiation of GABA(A) receptor function
Treat: status epilepticus (alcohol withdrawl) Not for chronic treatment bc of tolerance |
GABA
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Vigabatrin (Sabril)
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MOA: irreversible inhibitor of GABAT (enzyme for GABA catabolism) increasing GABA levels
Treat: adjunct in partial and secondary generalized |
GABA
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Tiagabine (Gabatril)
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MOA: inhibit GABA reuptake increasing amount of GABA at the synapse
Treat: adjunct in partial and secondarily generalized |
GABA
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Side effects of AEDs that increase GABA transmission
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HE, dizziness, confusion, sedation, fatigue, ataxia, diplopia
allergic rash |
CNS + rash
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Phenyloin (Dilantin)
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MOA: use-dependent blocker of Na+
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