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17 Cards in this Set
- Front
- Back
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PHENOBARBITAL
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GABA receptor agonist
inhibitor of AMPA receptors Drug-drug interactions teratogenic Addiction, withdrawal, and can cause apnea |
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BENZODIAZEPINES
-zolam -zepam |
GABA receptor agonist
Drug of choice for STATUS EPILEPTICUS Teratogenic |
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PRIMIDONE
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Prodrug converted to PHENOBARBITAL!!!! same as phenobarbital
bone marrow suppression, LUPUS, folate deficiency, SJS, nystagmus, CNS effects. inducer of hepatic enzymes. drug-drug interactions |
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CARBAMAZEPINE
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Blocks Na channels
Also used for bipolar disease, chronic pain, trigeminal neuralgia drug-drug interactions bone marrow suppression, SJS, SIADH, dizziness, cognitive effects. Teratogenic |
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VALPROIC ACID
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Inhibition of GABA transaminase and T Ca channels.
used for absence seizures Side effects: weight gain, GI Sx, sedation, hepatitis, folate deficiency. Teratogenic. |
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PHENYTOIN
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Na channel 1B blocker
gingival hyperplasia, lupus, SJS, folate deficiency, arrhythmias, hirsutism, and is teratogenic. Metabolized by CYP2C9. |
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FELBAMATE
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NMDA receptor antagonist and also influences GABA
Bone marrow suppression, severe hepatotoxicity |
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VIGABATRIN
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Inhibits the metabolism of GABA
excreted unchanged in the urine. No drug-drug interaction Side effects: weight gain, GI symptoms, hyperactivity, CNS effects. Teratogenic |
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LAMOTRIGINE
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blocks Na channels
SJS, teratogenic (category C), sleeping problems, CNS depression, leukopenia and interactions with other medications |
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TOPIRAMATE
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used to treat all types of epilepsy
inhibits AMPA cognitive function, weight loss, increase IOP contraindicated in G6PD Def |
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GABAPENTIN
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Inhibition of type N calcium channels
used mainly for pain management Eliminated by kidneys unchanged. no drug-drug interaction |
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PREGABALIN
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Excreted unchanged in urine
Inhibits N Ca channels and increases activity of glutamate decarboxylase |
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dizziness and drowsiness, weight gain, withdrawal syndrome
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Blocks the re-uptake of GABA
Side effects: impairment of cognitive function, weight gain. May induce seizures. Category C. Interactions with other drugs |
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ETHOSUXIMIDE
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Indicated for absence seizures.
SJS, lupus, CNS effects, gingival hyperplasia, bone marrow suppression, less hepatotoxic than valproic acid |
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ACETAZOLAMIDE
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for absence seizures.
Not metabolized by the liver |
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ZONISAMIDE
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blocks voltage gated sodium channels and type T calcium (absence seizures)
Shares many side effects with acetazolamide |
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LEVETIRACETAM
BRIVARACETAM |
inhibit SNAP on vesicles: no neurotrans release
irritability, parasthesia, anxiety, generally well tolerated often pyridoxine/Vit B6 is added |
