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22 Cards in this Set
- Front
- Back
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ANTICONVULSANT THERAPY
MECHANISM OF ACTION-4 |
b PREVENT EXCESSIVE DISCHARGE OF ABNORMAL NEURONS
b PREVENT DISCHARGE OF NORMAL NEURONS ADJACENT TO ABNORMAL AREA b RAISE THRESHOLD OF STIMULATION-depends on strenght of seizure b ACTIVATE INHIBITORY PATHWAYS |
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PHENYTOIN
b THERAPEUTIC USEs-4 ANTICONVULSANT THERAPY |
• generalize non-convulsive seizures (petit mal)
• febrile seizures • generalized convulsive seizures (gran mal) • seizures following withdrawal of short acting barbiturates |
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• generalize non-convulsive seizures (petit mal)
ANTICONVULSANT THERAPY |
doesnt effect muscles
cant respond or be attentive blank stare only eyelids move |
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• febrile seizuresANTICONVULSANT THERAPY
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effects children; bad influenza raises temp go to seizure
next fever get seizure |
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PHENYTOIN SIDE EFFECTS-5
ANTICONVULSANT THERAPY tolerance develops to which side effect? |
b HYPERPLASIA OF GUMS (gums grow over teeth)
b DERMATITIS(rash 1st week) b HIRSUITISM(abnormal hair growth) b GI UPSET b SEDATION - tolerance develops to this side effect |
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PHENYTOIN
b Toxicities ANTICONVULSANT THERAPY • |
Nystagmus is early sign
(eyes bounce bc blood levels are to high) |
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Food/Drug Interaction of Phenytoin
ANTICONVULSANT THERAPY |
• Folic acid supplementation may be needed
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ANTICONVULSANT THERAPY
Barbituates ______ is converted to what phenobarbital |
primidone
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ANTICONVULSANT THERAPY
Primidone |
pro-drug that is non abusive that is converted to phenobaribtal(no surge to brain)
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ANTICONVULSANT THERAPY
2 types of phenytoin |
oral vs liquid(not water soluble insteead use proplyne glycol) inject slowly
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ANTICONVULSANT THERAPY
Barbituates theraputic uses-3 |
Febrile seizures
• Convulsant seizures • Barbiturate withdrawal seizures |
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ANTICONVULSANT THERAPY
BARBITURATE PROPERTIES b Side effects? b Drug Interactions? |
Side effects - sedation
b Drug Interactions • Hepatic Induction - stimulates metabolism of other agents including other anticonvulsant agents |
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ANTICONVULSANT THERAPY
ETHOSUXIMIDE b Therapeutic Use |
• General non-convulsant seizures (petit mal)
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ANTICONVULSANT THERAPY
ETHOSUXIMIDE side effects-3 |
• sedation
• headache • dizziness |
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ANTICONVULSANT THERAPY
DIVALPROEX b Therapeutic Use?3 • b Side Effects?1 • |
Febrile Seizures
• Non-convulsant seizures • Convulsant Seizures Sedation |
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ANTICONVULSANT THERAPY
Benzodiazepines-2 |
b CLONAZEPAM
• Always used as adjunct therapy only • Tolerance develops to therapeutic properties b LORAZEPAM/DIAZEPAM • Intravenous use for status epilepticus |
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ANTICONVULSANT THERAPY
Benzodiazepines CLONAZEPAM • |
Always used as adjunct therapy only
• Tolerance develops to therapeutic properties |
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ANTICONVULSANT THERAPY
Benzodiazepines LORAZEPAM/DIAZEPAM where is this kept befor euse? injection facts? how should u inject? • |
Intravenous use for status epilepticus
needs to be refrigerated not water solubale soluble in propyne gycol must inject slowly |
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ANTICONVULSANT THERAPY
CARBAMAZEPINE b THERAPEUTIC USE-2 • b TOXICITY-1 • |
Partial Seizures
• Neurologic Pain(after seeral weeks stops working and needs to be increased. If dont increase and still want = addiction) Bone marrow depression: white blood cells decrease and become prone to infection |
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ANTICONVULSANT THERAPY
MISCELLANEOUS-2 |
b FOSPHENYTOIN - intravenous administration of phenytoin
b Gabapentin • Adjunct therapy for partial seizures • Neurologic Pain |
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FOSPHENYTOIN -
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intravenous administration of phenytoin
misc anti-conv |
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Gabapentin(nuerontin)
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• Adjunct therapy for partial seizures
• Neurologic Pain misc anti-conv |
