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8 Cards in this Set
- Front
- Back
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What are the main causes of seizures in animals? |
Idiopathic epilepsy (most common) Infectious - parasitic Neoplasia Toxin - snail pellets |
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What is phenobarbitone and what is its MOA? |
Barbiturate Binds to CNS Cl- channels opening them causing hyperpolarisation |
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What is meant by phenobarbitone inducing HMEs and what is the significance of this? |
Stimulates hepatic metabolic enzymes which are responsible for breaking drugs down. Means that the drug will become more readily broken down over time leading to breakthrough seizures. |
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What is potassium bromide and what is its MOA? |
Oldest of the anticonvulsants Unknown MOA Used in conjunction with phenobarbitone Requires large loading dose that may need to be staggered. |
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What is Levetiracetam and what is its MOA? |
New drug to veterinary medicine with unknown MOA |
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How doesLevetiracetam compare to phenobarbitone (benefits and weaknesses)? |
Benefits: Very few side-effects Little hepatic metabolism Doesn't induce HMEs Weaknesses: Much more expensive Has to be given more frequently |
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What is Gabapentin and when is it used? |
Recently released to Vet Med MOA not well understood Mainly only used when other anticonvulsants are producing unacceptable side effects. |
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What is Imepitoin and what is its MOA? |
Recently registered in Vet Med Partial benzodiazepine agonist - safer than diazepam - anxiolytic - no drug tolerance |
