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16 Cards in this Set
- Front
- Back
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Aspirin
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Antiplatelet drug
Blocks COX to inhibit formation of TXA2 (no aggregation and adherence) |
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Maximal effective dose of Aspirin
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50-320 mg/day
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Dipyridamole
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Antiplatelet drug and Vasodilator
Blocks phosphodiesterase Blocks Adenosine uptake Decreased platelet adherence Primary prophylaxis against thromboemboli for pts with artificial heart valves |
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Ticlopidine/Clopidogrel
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Anti-platelet drugs
Inhibit ADP from binding receptor (P2Y) that normally decreases cAMP Reduces risk of thrombosis in patients with stroke precursors |
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Abciximab
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Ab against IIb/IIIa receptor
Used with angioplasty for coronary thrombosis |
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Eptifibatide
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Peptide inhibitor of IIb/IIIa's fibrinogen binding site
Used for Acute Coronary Syndrome and Angioplasty |
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Tirofiban
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Nonpeptide inhibitor of IIb/IIIa's fibrinogen binding site
Used for Acute Coronary Syndrome and Angioplasty |
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Warfarin
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Antagonist of Vit K
2-10 mg/day Peak effect in 36-72 hrs. Primary prophylaxis against thrombi Administer Vit K to antagonize |
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Heparin
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Endogenously interacts with AT to inhibit FIX and FX
Given parenterally Liver metab and Renal excret Does not cross placenta Given before and after surgery Protamine Sulfate antagonist |
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Danaparoid
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Non-heparin glycosaminoglycans that promote AT action
Not available in US |
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Hirudin
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Most potent naturally inhibitor of thrombin (AT independent)
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Lepirudin
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AT independent thrombin inhibitor used for patients with HIT
Renally excreted so caution with patients in renal failure |
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Argatroban
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Binds to catalytic site of thrombin and inactivates
Alternate to Lepirudin for patients in renal failure with HIT |
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Drotrecogin alpha
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Recombinant form of human activated protein C
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Streptokinase
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Forms complex with plasminogen that activates it so more plasminogen is coverted to plasmin
Used to establish blood flow after MI |
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tPA
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High affinity for fibrin and produces selective activation of plasminogen
Establishes reperfusion |
