Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
5 Cards in this Set
- Front
- Back
|
cobalamin MOA
|
MOA: cofactor for methylmalonyl CoA mutase, for transfer of methyl groups
-has porphyrin like ring -cyanocobalamin/hydroxycobalamin converted to active forms -essential for normal maturation erythroblasts, epithelial cells -bound to plasma glycoprotein TRANSCOBALAMIN II -excess in liver |
|
|
cyanobalamin injection, hydroxycobalamin
mecobalamin pharmK |
pharmK-1-5ug absorbed, complex w/ intrinsic factor (parietal cells), absorb in distal ileum
|
|
|
cyanobalamin injection, hydroxycobalamin
mecobalamin indication/dosage |
oral: 500-1000ug, parenteral as cyanocobalamin or hydroxycobalamin
-100-1000ug of vitB12 IM daily/ every other day for 1-2 weeks, then maintenance of 100-1000ug IM once a month for life -oral used for pernicious anemia 500ug BID -megaloblastic anemia GIT- glossitis, dyspepsia bc gastric mucosa atrophy -neurlogical abnormalities, optic atrophy, mental |
|
|
folic acid pharmK
|
avg diet 500-700ug
50-200 absorbed in prox jejunum -pregnant absorb 300-400ug folic acid daily source- yeast, liver, kdiney, greens excrete: urine, stool -metabolic fxn: THYMYDILATE synthesis |
|
|
folic acid indications
|
megaloblastic anemia
oral prep: 400ug folic- adults 600ug pregnant 500ug nursing |
