Anticoagulants And Vitamin K

Front 1

heparin

Back 1

- parenteral anticoagulant
- catalyzes inactivation of clotting factors by antithrombin III
- used in low doses post-op

Front 2

warfarin

Back 2

- oral anticoagulant
- delayed action since it prevents synthesis of clotting factors
- antagonizes vitamin K

Front 3

drug interactions in clotting

Back 3

- phenylbutazone displaces warfarin from plasma proteins
- barbiturates stimulate metabolic inactivation of anticoagulants
- antibiotics decrease available vitamin K, increasing the effectiveness of anticoagulants
- large vitamin K doses overcome the inhibition

Front 4

vitamin K

Back 4

- induces the post-translational carboxylation of factors 2, 7, 9, 10, proteins C and S, prothrombin and maybe tissue factor

Front 5

class 1 of platelet aggregation inhibitors

Back 5

- aspirin, indomethacin, sulfinpyrazone inhibit cyclo-oxygenase and block TXA2 formation

Front 6

dipyrimadole

Back 6

- platelet inhibitor which increases intracellular levels of inhibitory messenger cAMP

Front 7

clopidogrel and ticlopidine

Back 7

reduce platelet aggregation by inhibiting the ADP pathway of platelet aggregation

Front 8

abciximab, eptifibatide, tirofiban

Back 8

glycoprotein IIb/IIIa inhibitors; block the final common pathway for platelet aggregation

Front 9

streptokinase and urokinase

Back 9

cause systemic plasmin formation, which degrades numerous circulating proteins like fibrinogen and coagulation factors

Front 10

t-PA (tissue plasminogen activators)

Back 10

bind tightly to fibrin and restricts its activity to vicinity of the thrombus